Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.
Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.
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DOI：
10.1016/j.jaac.2013.07.008
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发表时间：
2013-10
影响因子：
13.3
通讯作者：
Yang TT
中科院分区：
文献类型：
--
作者：
Ho TC;Wu J;Shin DD;Liu TT;Tapert SF;Yang G;Connolly CG;Frank GK;Max JE;Wolkowitz O;Eisendrath S;Hoeft F;Banerjee D;Hood K;Hendren RL;Paulus MP;Simmons AN;Yang TT
虽然大量文献报道了成年抑郁症患者的局部脑血流异常，但这些研究通常需要向受试者注射放射性同位素。然而，动脉自旋标记(ASL)的最新发展使得无创测量rCBF成为可能。目前，还没有发表的ASL研究检查患有抑郁症的青少年的脑血流灌注。因此，本研究的目的是使用一种新开发的ASL技术：假连续动脉自旋标记(PCASL)来检查青少年抑郁症患者的基线脑血流灌注。25名未服药的青少年(年龄13-17岁)被诊断为严重抑郁障碍(MDD)，26名匹配的对照组接受了功能磁共振成像。通过一种新的PCASL方法测量基线rCBF，该方法优化了标记效率。基于体素的全脑分析显示，抑郁症组的额叶、边缘、边缘和扣带状回血流明显降低(p<；0.05，校正后)。在扣带回、壳回和梭形回也观察到高灌注区(p<；0.05，校正)。同样，兴趣区分析显示抑郁症患者杏仁核和岛叶血流低，壳核和上岛也有高血流(p<；0.05，校正后)。患有抑郁症的青少年和健康青少年在执行、情感和运动网络上的rCBF似乎不同。这些区域的功能障碍可能导致青少年抑郁症常见的认知、情绪和精神运动症状。这些发现指出了青少年抑郁症的可能生物标志物，可以为早期干预和治疗提供信息，并建立了一种使用PCASL在临床和健康青少年人群中非侵入性测量rCBF的方法。
While substantial literature has reported regional cerebral blood flow (rCBF) abnormalities in adults with depression, these studies commonly necessitated the injection of radioisotopes into subjects. The recent development of arterial spin labeling (ASL), however, allows for noninvasive measurements of rCBF. Currently, no published ASL studies have examined cerebral perfusion in adolescents with depression. Thus, the aim of the present study was to examine baseline cerebral perfusion in adolescent depression using a newly developed ASL technique: pseudocontinuous arterial spin labeling (PCASL). 25 medication-naive adolescents (ages 13–17 years) diagnosed with major depressive disorder (MDD) and 26 well-matched controls underwent functional magnetic resonance imaging. Baseline rCBF was measured via a novel PCASL method that optimizes tagging efficiency. Voxel-based whole brain analyses revealed significant frontal, limbic, paralimbic, and cingulate hypoperfusion in the group with depression (p<0.05, corrected). Hyperperfusion was also observed within the subcallosal cingulate, putamen, and fusiform gyrus (p<0.05, corrected). Similarly, region-of-interest analyses revealed amygdalar and insular hypoperfusion in the group with depression, as well as hyperperfusion in the putamen and superior insula (p<0.05, corrected). Adolescents with depression and healthy adolescents appear to differ on rCBF in executive, affective, and motor networks. Dysfunction in these regions may contribute to the cognitive, emotional, and psychomotor symptoms commonly present in adolescent depression. These findings point to possible biomarkers for adolescent depression that could inform early interventions and treatments and establishes a methodology for using PCASL to noninvasively measure rCBF in clinical and healthy adolescent populations.
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影响因子：
7.6
作者：
Borogovac A;Asllani I
通讯作者：
Asllani I
DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW
影响因子：
10.6
作者：
Auer, DP;Pütz, B;Holsboer, F
通讯作者：
Holsboer, F
DOI：
10.1097/01.wcb.0000071887.63724.b2
发表时间：
2003-07-01
影响因子：
6.3
作者：
Brown, GG;Zorrilla, LTE;Buxton, RB
通讯作者：
Buxton, RB
影响因子：
5.7
作者：
Chen, Yu-Han;Dammers, Juergen;Mathiak, Klaus
通讯作者：
Mathiak, Klaus