Linking heart rate variability to psychological health and brain structure in adolescents with and without conduct disorder.
Linking heart rate variability to psychological health and brain structure in adolescents with and without conduct disorder.
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将心率变异性与有或没有品行障碍的青少年的心理健康和大脑结构联系起来。
DOI：
10.3389/fpsyt.2023.1101064
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发表时间：
2023
影响因子：
4.7
通讯作者：
Stadler, Christina
中科院分区：
文献类型：
--
作者：
Cubillo, Ana;Tkalcec, Antonia;Oldenhof, Helena;Unternaehrer, Eva;Raschle, Nora;Kohls, Gregor;Nauta-Jansen, Lucres;Hervas, Amaia;Fernandez-Rivas, Aranzazu;Konrad, Kerstin;Popma, Arne;Freitag, Christine;de Brito, Stephane;Fairchild, Graeme;Stadler, Christina
关键词：
心率变异性（HRV）的措施已被建议在健康个体作为一个潜在的指标的自我调节技能，其中包括认知和情绪调节方面。然而，对一系列精神疾病患者的研究主要集中在静息时异常低HRV与特别是情绪调节困难之间的潜在关联。情绪调节缺陷已被报道在患者行为障碍（CD），然而，这些情绪调节缺陷和HRV措施之间的关联尚未得到充分理解。本研究调查（i）之间的关联的特异性HRV和情绪调节技能的青少年与CD和（ii）之间的关联HRV和灰质脑容量的中央自主神经网络的关键领域，参与自我调节过程，如小脑，外侧/内侧前额叶皮质或杏仁核。作为欧洲多中心项目（FemNAT-CD）的一部分，从9-18岁的青少年（693 CD（427 F）/753典型发育青年（TD）（500 F））中收集HRV的呼吸性窦性心律失常（RSA）测量值。计算逆效率分数，速度-准确性权衡措施，以评估情绪和认知调节能力在情绪去/不去任务。RSA和任务性能之间的关联进行了测试，使用多层次回归模型。纳入了577例受试者的T1加权结构MRI数据（CD 257例（125 F）; TD 320例（186 F））。使用CerebroMatic工具箱创建定制的组织概率图和DARTEL模板，使用CAT 12分割脑图像，然后进行2 × 2（性别×组）全因子ANOVA，RSA作为关注的回归变量。RSA和任务绩效之间没有显着的关联，无论是在情绪调节，也没有在认知调节试验。然而，在所有受试者中，RSA与左侧延髓的区域灰质体积呈正相关（pFWE = 0.011）。在所有受试者中，RSA与左脑岛灰质体积增加有关。因此，我们的研究结果表明，低RSA在休息可能是一个潜在的自我调节困难的贡献或诱发因素。考虑到大脑皮层在情绪和认知调节过程中的作用，这些大脑结构差异可能会影响其中任何一个。
Heart rate variability (HRV) measures have been suggested in healthy individuals as a potential index of self-regulation skills, which include both cognitive and emotion regulation aspects. Studies in patients with a range of psychiatric disorders have however mostly focused on the potential association between abnormally low HRV at rest and specifically emotion regulation difficulties. Emotion regulation deficits have been reported in patients with Conduct Disorder (CD) however, the association between these emotion regulation deficits and HRV measures has yet to be fully understood. This study investigates (i) the specificity of the association between HRV and emotion regulation skills in adolescents with and without CD and (ii) the association between HRV and grey matter brain volumes in key areas of the central autonomic network which are involved in self-regulation processes, such as insula, lateral/medial prefrontal cortices or amygdala. Respiratory sinus arrhythmia (RSA) measures of HRV were collected from adolescents aged between 9–18 years (693 CD (427F)/753 typically developing youth (TD) (500F)), as part of a European multi-site project (FemNAT-CD). The Inverse Efficiency Score, a speed-accuracy trade-off measure, was calculated to assess emotion and cognitive regulation abilities during an Emotional Go/NoGo task. The association between RSA and task performance was tested using multilevel regression models. T1-weighted structural MRI data were included for a subset of 577 participants (257 CD (125F); 320 TD (186F)). The CerebroMatic toolbox was used to create customised Tissue Probability Maps and DARTEL templates, and CAT12 to segment brain images, followed by a 2 × 2 (sex × group) full factorial ANOVA with RSA as regressor of interest. There were no significant associations between RSA and task performance, neither during emotion regulation nor during cognitive regulation trials. RSA was however positively correlated with regional grey matter volume in the left insula (pFWE = 0.011) across all subjects. RSA was related to increased grey matter volume in the left insula across all subjects. Our results thus suggest that low RSA at rest might be a contributing or predisposing factor for potential self-regulation difficulties. Given the insula’s role in both emotional and cognitive regulation processes, these brain structural differences might impact either of those.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
17.7
作者：
Alegria, Analucia A.;Radua, Joaquim;Rubia, Katya
通讯作者：
Rubia, Katya
焦虑症与心率变异性降低有关：荟萃分析。
影响因子：
4.7
作者：
Chalmers JA;Quintana DS;Abbott MJ;Kemp AH
通讯作者：
Kemp AH
DOI：
10.1016/j.jaac.2010.01.016
发表时间：
2010-05-01
影响因子：
13.3
作者：
Burke, Jeffrey D.;Hipwell, Alison E.;Loeber, Rolf
通讯作者：
Loeber, Rolf
DOI：
10.1056/nejmra1315612
发表时间：
2014-12-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Blair RJ;Leibenluft E;Pine DS
通讯作者：
Pine DS