Functionalizing calcium phosphate biomaterials with antibacterial silver particles.
Functionalizing calcium phosphate biomaterials with antibacterial silver particles.
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DOI：
10.1002/adma.201203370
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发表时间：
2013-02-25
影响因子：
29.4
通讯作者：
Murphy, William L.
中科院分区：
文献类型：
--
作者：
Lee, Jae Sung;Murphy, William L.
植入物相关感染是医疗器械植入物最严重的术后并发症之一，包括假体关节（例如髋关节、膝关节和肩关节）和骨折固定硬件。 [1, 2] 由于严格的卫生方案和术中全身预防性治疗，与骨科植入物相关的感染率已降至 5% 以下。 [3]然而，随着人口老龄化和娱乐活动参与度的增加，对手术植入的需求不断增加，此类感染的总数一直在不断增加。 [4]及时诊断种植体相关感染是一项重大挑战，长期全身抗生素治疗可能无法有效治疗已确定的感染。 [2]因此，术后感染通常需要复杂的额外外科手术，例如清创、假体移除和重新植入。即使全身抗生素治疗也会引起一些问题，例如全身毒性、低效率和需要住院治疗。鉴于此，非常需要在植入部位延长抗菌药物的递送时间，以提供高局部抗生素浓度而不产生全身毒性，从而预防术后植入相关的感染。磷酸钙 (CaP) 矿物质是脊椎动物骨骼和牙齿的主要无机成分。羟基磷灰石 (HAP)、β-磷酸三钙 (β-TCP) 和双相磷酸钙 (BCP) 是 CaP 矿物质的典型例子，众所周知，它们能够与周围骨组织很好地结合并促进骨组织生长。 [5]因此，CaP生物材料通常在骨科和牙科手术中用作骨空隙填充物[6]或
Implant-associated infections are among the most serious post-surgical complications of medical device implants, including prosthetic joints (eg, hip, knee and shoulder) and fracture fixation hardware.[1, 2] Infection rates related to orthopedic implants have been reduced to below 5% owing to strict hygienic protocols and intraoperative systemic prophylactic treatment.[3] However, the overall number of such infections has been continuously increasing with growing demands for surgical implantation as a result of population aging and increasing participation in recreational activities.[4] Timely diagnosis of implant-associated infections is a significant challenge, and established infections may not be effectively treated with long-term systemic antibiotic therapy.[2] Therefore, postsurgical infections often require complex additional surgical procedures such as debridement, prosthesis removal and re-implantation. Even systemic antibiotic treatment raises several concerns, such as systemic toxicity, low efficiency and need for hospitalization. Given this context, extended delivery of antimicrobial agents at the site of implantation is highly desirable to offer high local antibiotic concentration without systemic toxicity and thereby prevent postoperative, implant-associated infections.Calcium phosphate (CaP) mineral is the main inorganic component of vertebrate bone and teeth. Hydroxyapatite (HAP), β-tricalcium phosphate (β-TCP) and biphasic calcium phosphate (BCP) represent typical examples of CaP minerals, which are known to integrate well with surrounding bone tissue and facilitate bone tissue growth.[5] Therefore, CaP biomaterials are commonly used in orthopedic and dental surgery as bone void fillers [6] or
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影响因子：
9.7
作者：
Choi, Siyoung;Murphy, William L.
通讯作者：
Murphy, William L.
影响因子：
2.9
作者：
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1.7
作者：
Arciola, CR;An, YH;Montanaro, L
通讯作者：
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影响因子：
4.3
作者：
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Simms, M
影响因子：
4.3
作者：
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通讯作者：
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