Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections.
Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections.
复制标题
DOI：
10.1093/rb/rbac013
复制
发表时间：
2022
影响因子：
6.7
通讯作者：
Zhao, Qi
中科院分区：
文献类型：
--
作者：
Liang, Xinjin;Zhang, Shuai;Gadd, Geoffrey Michael;McGrath, John;Rooney, David W.;Zhao, Qi
针道感染（PTIs）是骨折外固定的常见并发症，目前预防PTIs的策略已被证明无效。最近的进展表明，使用具有局部抗菌活性的抗感染涂层可以解决这个问题。硒因其具有良好的抑菌和成膜作用而被认为是一种很有前途的抗感染药物。在这项研究中，硒纳米颗粒（SeNPs）通过具有成本效益的真菌介导的生物回收方法合成，并表现出优异的稳定性和均匀性。为了研究它们的抗感染潜力，通过化学镀工艺将SeNPs掺杂在银涂层中，并且测试银-硒（Ag-Se）涂层对金黄色葡萄球菌F1557和大肠杆菌WT F1693的抗菌和抗微生物膜性能以及在模拟体液中的耐腐蚀性。发现Ag-Se涂层显著抑制表面上的金黄色葡萄球菌生长和生物膜形成，在3天后与Ag和Ag-PTFE涂覆的表面相比，减少了81.2%和59.7%的活细菌粘附。与Ag涂层相比，Ag-Se涂层还表现出改善的耐腐蚀性，导致Ag+的受控释放，这反过来降低了对hFOB的细胞毒性的风险。这些结果表明，真菌衍生的SeNP可能具有用作植入物涂层以预防PTI的潜力。
Pin-tract infections (PTIs) are a common complication of external fixation of fractures and current strategies for preventing PTIs have proven to be ineffective. Recent advances show that the use of anti-infection coatings with local antibacterial activity may solve this problem. Selenium has been considered as a promising anti-infection agent owing to its antibacterial and antibiofilm activities. In this study, selenium nanoparticles (SeNPs) were synthesized via a cost-effective fungi-mediated biorecovery approach and demonstrated excellent stability and homogeneity. To investigate their anti-infection potential, the SeNPs were doped in silver coatings through an electroless plating process and the silver–selenium (Ag–Se) coatings were tested for antibacterial and antibiofilm properties against Staphylococcus aureus F1557 and Escherichia coli WT F1693 as well as corrosion resistance in simulated body fluid. It was found that the Ag–Se coating significantly inhibited S.aureus growth and biofilm formation on the surface, reducing 81.2% and 59.7% of viable bacterial adhesion when compared with Ag and Ag–PTFE-coated surfaces after 3 days. The Ag–Se coating also exhibited improved corrosion resistance compared with the Ag coating, leading to a controlled release of Ag+, which in turn reduced the risk of cytotoxicity against hFOBs. These results suggest that the fungal-derived SeNPs may have potential in use as implant coatings to prevent PTIs.
登录
查看更多内容
影响因子：
1.7
作者：
Brayda-Bruno, M;Fini, M;Giardino, R
通讯作者：
Giardino, R
影响因子：
9.5
作者：
Huang, Tao;Holden, James A.;O'Connor, Andrea J.
通讯作者：
O'Connor, Andrea J.
影响因子：
14
作者：
Lim, Jung Yul;Shaughnessy, Michael C.;Donahue, Henry J.
通讯作者：
Donahue, Henry J.
影响因子：
4.1
作者：
Geoffrion, Luke D.;Hesabizadeh, Tina;Guisbiers, Gregory
通讯作者：
Guisbiers, Gregory
影响因子：
8
作者：
Atran, Phong;O'Brien-Simpson, Neil;O'Connor, Andrea J.
通讯作者：
O'Connor, Andrea J.