Role of Hydrogen Sulfide in Retinal Diseases.
Role of Hydrogen Sulfide in Retinal Diseases.
复制标题
硫化氢在视网膜疾病中的作用
DOI：
10.3389/fphar.2017.00588
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发表时间：
2017
影响因子：
5.6
通讯作者：
Yang L
中科院分区：
文献类型：
--
作者：
Du J;Jin H;Yang L
硫化氢（H2S）作为第三种气体递质，在神经系统、心血管系统、呼吸系统和胃肠系统等多种系统的生理和病理生理中起着至关重要的作用。其作用机制包括抑制缺血性损伤、减轻氧化应激损伤、调节细胞凋亡和减轻不同系统的炎症反应，但其作用机制尚未完全清楚。最近，H2S及其内源性合成途径在哺乳动物视网膜中被发现。本文综述了H2S的产生和代谢，以及H2S在视网膜生理学和不同视网膜疾病（包括视网膜变性疾病和血管疾病）中的作用的证据。在视网膜中，H2S在胱硫醚-β-合酶、胱硫醚-γ-裂解酶和来自L-半胱氨酸的3-巯基丙酮酸硫转移酶的存在下产生。内源性H2S在视网膜中的作用及其生理效应至今仍不清楚。然而，大量证据表明，视网膜源性H2S在视网膜疾病的发病机制中可能起保护或有害作用。例如，通过调节Ca 2+内流，H2S可以保护视网膜神经元免受光诱导的变性。H2S预处理可介导视网膜缺血再灌注损伤中视网膜神经节细胞的抗凋亡作用。在大鼠中用H2S治疗通过抑制氧化应激和减少炎症来缓解糖尿病视网膜病变。进一步的研究将大大提高我们对视网膜疾病的病理生理机制的理解，以及H2S相关治疗视网膜疾病的潜力。
As the third gasotransmitter, hydrogen sulfide (H2S) plays a crucial role in the physiology and pathophysiology of many systems in the body, such as the nervous, cardiovascular, respiratory, and gastrointestinal systems. The mechanisms for its effects, including inhibiting ischemic injury, reducing oxidative stress damage, regulating apoptosis, and reducing the inflammation reaction in different systems, have not been fully understood. Recently, H2S and its endogenous synthesis pathway were found in the mammalian retina. This review describes the production and the metabolism of H2S and the evidence of a role of H2S in the retina physiology and in the different retinal diseases, including retinal degenerative diseases and vascular diseases. In the retina, H2S is generated in the presence of cystathionine-β-synthase, cystathionine-γ-lyase, and 3-mercaptopyruvate sulfurtransferase from L-cysteine. The role of endogenous H2S and its physiologic effect in the retina are still elusive. However, strong evidence shows that retina-derived H2S might play protective or deleterious role in the pathogenesis of retinal diseases. For example, by regulating Ca2+ influx, H2S can protect retinal neurons against light-induced degeneration. H2S preconditioning can mediate the anti-apoptotic effect of retinal ganglion cells in retinal ischemia/reperfusion injury. Treatment with H2S in rats relieves diabetic retinopathy by suppressing oxidative stress and reducing inflammation. Further studies would greatly improve our understanding of the pathophysiologic mechanisms responsible for retinal diseases and the potential for the H2S-related therapy of the retinal diseases as well.
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影响因子：
4.4
作者：
Gersztenkorn D;Coletta C;Zhu S;Ha Y;Liu H;Tie H;Zhou J;Szabo C;Zhang W;Motamedi M
通讯作者：
Motamedi M
影响因子：
1.7
作者：
Aizu, Y;Katayama, H;Oyanagi, K
通讯作者：
Oyanagi, K
影响因子：
3.5
作者：
Martin C;Houitte D;Guillermier M;Petit F;Bonvento G;Gurden H
通讯作者：
Gurden H
影响因子：
7.4
作者：
Hughes, Martin N.;Centelles, Miguel N.;Moore, Kevin P.
通讯作者：
Moore, Kevin P.
DOI：
10.1016/s0896-1549(01)00010-4
发表时间：
2002-03-01
期刊：
Ophthalmology clinics of North America
影响因子：
--
作者：
Lu, Ming;Adamis, Anthony P
通讯作者：
Adamis, Anthony P