Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.
Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.
复制标题
超声弹性成像评估视神经乳头和视乳头周围巩膜的生物力学特性。
DOI：
10.1016/j.ultras.2020.106263
复制
发表时间：
2021-03
期刊：
影响因子：
4.2
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Qian X;Li R;Lu G;Jiang L;Kang H;Kirk Shung K;Humayun MS;Zhou Q
目的通过超声弹性成像系统定量研究猪眼视神经乳头（ONH）和视乳头周围巩膜（PPS）在眼内压（IOP）升高和降低时的生物力学特性。使用我们的高分辨率超声成像系统评估ONH和PPS的杨氏模量，该系统利用机械振动器来诱导剪切波，并利用离轴对准的40 MHz针换能器来跟踪沿着波传播方向的微米级位移。在本研究中，对预加载6 mmHg至30 mmHg IOP的总共8只离体猪眼进行成像。为了更好地了解不同IOP对生物力学的影响，研究了IOP的增加和降低。ONH的杨氏模量的增加（6 mmHg时为92.4 ± 13.9 kPa，30 mmHg时为224.7 ± 71.1 kPa）和PPS在重建的剪切波弹性模量（SWE）成像中可以观察到眼压升高后的眼压（6 mmHg时为176.8 ± 14.3 kPa，30 mmHg时为573.5 ± 64.4 kPa），而B-模式结构图像几乎保持不变。此外，对于相同的IOP水平，与IOP升高相比，随着IOP降低，ONH和PPS都具有更硬的趋势。我们的研究结果表明，使用我们的超声弹性成像系统的可行性，以调查后眼的刚度映射与高分辨率的增加和减少IOP，使这项技术可能有用的青光眼。
To quantitatively investigate both optic nerve head (ONH) and peripapillary sclera (PPS) biomechanical properties of porcine eyes through an ultrasonic elastography imaging system in response to both increasing and decreasing intraocular pressure (IOP). The Young’s modulus of the ONH and PPS were assessed using our high resolution ultrasonic imaging system which utilized a mechanical shaker to induce shear waves and an off-axis aligned 40 MHz needle transducer to track micron-level displacement along the direction of wave propagation. In this study, imaging on a total of 8 ex vivo porcine eyes preloaded with IOPs from 6 mmHg to 30 mmHg was performed. To have a better understanding of the effect of varying IOP on biomechanics, both increasing and decreasing IOPs were investigated. The increase of the Young’s modulus of ONH (92.4 ± 13.9 kPa at 6 mmHg to 224.7 ± 71.1 kPa at 30 mmHg) and PPS (176.8 ± 14.3 kPa at 6 mmHg to 573.5 ± 64.4 kPa at 30 mmHg) following IOP elevation could be observed in the reconstructed Young’s modulus of the shear wave elasticity (SWE) imaging while the B-mode structural images remained almost unchanged. In addition, for the same IOP level, both ONH and PPS have a tendency to be stiffer with decreasing IOP as compared to increasing IOP. Our results demonstrate the feasibility of using our ultrasonic elastography system to investigate the stiffness mapping of posterior eye with high resolution in both increasing and decreasing IOPs, making this technique potentially useful for glaucoma.
登录
查看更多内容
DOI：
10.1109/tbme.2018.2853571
发表时间：
2019-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Qian X;Ma T;Shih CC;Heur M;Zhang J;Shung KK;Varma R;Humayun MS;Zhou Q
通讯作者：
Zhou Q
影响因子：
4.4
作者：
Pavlatos E;Ma Y;Clayson K;Pan X;Liu J
通讯作者：
Liu J
影响因子：
4.4
作者：
Sigal, IA;Flanagan, JG;Ethier, CR
通讯作者：
Ethier, CR
金刚石夹层对TiAlN薄膜与碳钢滑动摩擦性能的影响
影响因子：
1.1
作者：
Lei, X. L.;He, Y.;Sun, F. H.
通讯作者：
Sun, F. H.
影响因子：
9.7
作者：
Jan NJ;Sigal IA
通讯作者：
Sigal IA