Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release.
Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release.
复制标题
多功能纳米胶囊，用于同时封装亲水性和疏水性化合物以及按需释放。
DOI：
10.1021/nn205023w
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发表时间：
2012-03-27
期刊：
影响因子：
17.1
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Hu SH;Chen SY;Gao X
Cocktail therapy by delivering multiple drugs to diseased cells can elicit synergistic therapeutic effects and better modulate the complex cell signaling network. Besides selection of drug combinations, a difficulty in delivery is how to encapsulate drugs with various solubility into a common vehicle, particularly when both hydrophobic and hydrophilic compounds are involved. Furthermore, it is highly desirable that the drug release profile can be controlled in an on-demand fashion for balanced therapeutic and side effects. Based on a simple and scalable double-emulsion approach, we report a new class of nanocapsules that can solve these problems simultaneously. Further linking the nanocapsules with peptides targeting cell surface integrins leads to significantly enhanced cell uptake of the nanocapsules. Intracellular drug release triggered by external stimuli has also been achieved without affecting cell viability. Further development of this technology should open exciting opportunities in treating tough diseases such as cancer, cardiovascular diseases, neurological disorders, and infectious diseases.
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影响因子：
13.3
作者：
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通讯作者：
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通讯作者：
Le Visage, Catherine