Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: a meta-analysis.
Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: a meta-analysis.
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DOI：
10.1371/journal.pone.0002468
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发表时间：
2008-06-25
期刊：
影响因子：
3.7
通讯作者：
Vacanti J
中科院分区：
文献类型：
--
作者：
Stahl JE;Kreke JE;Malek FA;Schaefer AJ;Vacanti J
The ability to preserve organs prior to transplant is essential to the organ allocation process. The purpose of this study is to describe the functional relationship between cold-ischemia time (CIT) and primary nonfunction (PNF), patient and graft survival in liver transplant. To identify relevant articles Medline, EMBASE and the Cochrane database, including the non-English literature identified in these databases, was searched from 1966 to April 2008. Two independent reviewers screened and extracted the data. CIT was analyzed both as a continuous variable and stratified by clinically relevant intervals. Nondichotomous variables were weighted by sample size. Percent variables were weighted by the inverse of the binomial variance. Twenty-six studies met criteria. Functionally, PNF% = −6.678281+0.9134701*CIT Mean+0.1250879*(CIT Mean−9.89535)2−0.0067663*(CIT Mean−9.89535)3, r2 = .625, , p<.0001. Mean patient survival: 93 % (1 month), 88 % (3 months), 83 % (6 months) and 83 % (12 months). Mean graft survival: 85.9 % (1 month), 80.5 % (3 months), 78.1 % (6 months) and 76.8 % (12 months). Maximum patient and graft survival occurred with CITs between 7.5–12.5 hrs at each survival interval. PNF was also significantly correlated with ICU time, % first time grafts and % immunologic mismatches. The results of this work imply that CIT may be the most important pre-transplant information needed in the decision to accept an organ.
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影响因子：
0.9
作者：
Dette, K;Knoop, M;Neuhaus, P
通讯作者：
Neuhaus, P
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
6.2
作者：
FURUKAWA, H;TODO, S;STARZL, TE
通讯作者：
STARZL, TE
DOI：
10.1016/0197-2456(81)90056-8
发表时间：
1981-01-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
CHALMERS, TC;SMITH, H;AMBROZ, A
通讯作者：
AMBROZ, A
影响因子：
29.4
作者：
CALMUS, Y;CYNOBER, L;GIBOUDEAU, J
通讯作者：
GIBOUDEAU, J