CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.
CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.
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CAR-1 是一种与 mRNA 脱帽成分 DCAP-1 一起定位的蛋白质，是秀丽隐杆线虫胚胎中胞质分裂和 ER 组织所必需的。
DOI：
10.1091/mbc.e05-09-0874
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发表时间：
2006
影响因子：
3.3
通讯作者：
White,JohnG
中科院分区：
文献类型：
--
作者：
Squirrell,JayneM;Eggers,ZacharyT;Luedke,Nancy;Saari,Bonnie;Grimson,Andrew;Lyons,GaryE;Anderson,Philip;White,JohnG
一个细胞分裂成两个需要多个组件的协调。我们描述了一个基因，car-1，其产物可能提供了不同的细胞过程之间的联系。在秀丽隐杆线虫中抑制car-1表达会导致后期胞质分裂失败：卵裂沟进入，但随后退化，纺锤体中间区未能形成，即使中间区成分存在。在胞质分裂的最后阶段，通常在卵裂沟的顶点处形成的膜的局部积聚没有发生，内质网的组织异常，表明膜运输中断。car-1基因在许多物种中都有同源物，包括与RNA结合蛋白相关的蛋白质。CAR-1定位于P颗粒（生殖系特异性核糖核蛋白颗粒）和离散的发育调节的细胞质灶。这些病灶还含有DCAP-1，一种参与mRNA脱帽的蛋白质。因此，CAR-1，一种可能与RNA代谢相关的蛋白质，在胞质分裂的晚期阶段起着重要作用，表明在C. elegansembryo。
The division of one cell into two requires the coordination of multiple components. We describe a gene,car-1, whose product may provide a link between disparate cellular processes. Inhibition ofcar-1expression inCaenorhabditis elegansembryos causes late cytokinesis failures: cleavage furrows ingress but subsequently regress and the spindle midzone fails to form, even though midzone components are present. The localized accumulation of membrane that normally develops at the apex of the cleavage furrow during the final phase of cytokinesis does not occur and organization of the endoplasmic reticulum is aberrant, indicative of a disruption in membrane trafficking. Thecar-1gene has homologues in a number of species, including proteins that associate with RNA binding proteins. CAR-1 localizes to P-granules (germ-line specific ribonucleoprotein particles) and discrete, developmentally regulated cytoplasmic foci. These foci also contain DCAP-1, a protein involved in decapping mRNAs. Thus, CAR-1, a protein likely to be associated with RNA metabolism, plays an essential role in the late stage of cytokinesis, suggesting a novel link between RNA, membrane trafficking and cytokinesis in theC. elegansembryo.
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