Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury.
Refining environmental enrichment to advance rehabilitation based research after experimental traumatic brain injury.
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DOI：
10.1016/j.expneurol.2017.04.013
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发表时间：
2017-08
影响因子：
5.3
通讯作者：
Kline AE
中科院分区：
文献类型：
--
作者：
Radabaugh HL;LaPorte MJ;Greene AM;Bondi CO;Lajud N;Kline AE
典型的环境丰富(EE)范例，包括实验性创伤性脑损伤(TBI)后的持续暴露，促进了行为和组织学上的好处。然而，康复在诊所中通常是缩写的，并在每天的多次会议中进行。虽然最近的研究表明，每天一次6小时的EE具有与连续EE相当的好处，但将治疗分成两个较短的疗程可能会增加新颖性，并最终促进康复。因此，这项研究的目的是验证这样一种假设，即每天进行两次3小时的EE治疗与一次6小时的治疗相比，每天进行两次3小时的临床前神经康复治疗将显著改善功能和组织学结果。麻醉的成年雄性大鼠接受中到重度损伤(4m/S，2.8 mm组织变形)或假手术的皮质撞击，然后随机分成三组，分别接受标准住房、单一的6小时EE或每天2次3小时的EE，持续3周。分别于术后1~5d和14~19d评定运动功能(横梁平衡/横越)和空间学习记忆获得(Morris水迷宫)。第21天测定皮质损伤体积。这两种EE条件都改善了运动功能和空间学习的获得，并相对于STD住房减少了皮质病变体积(p<；0.05)，但在任何终点上彼此没有区别(p>；0.05)。这些发现重复了以前的工作，表明每天6小时的EE足以在脑损伤后赋予行为和组织学好处，并通过证明无论6小时的EE是如何累积的，这些好处都是可比较的。这一发现的相关性在于，它可以外推到临床，并可能使无法忍受单一延长神经康复期的患者受益。
The typical environmental enrichment (EE) paradigm, which consists of continuous exposure after experimental traumatic brain injury (TBI), promotes behavioral and histological benefits. However, rehabilitation is often abbreviated in the clinic and administered in multiple daily sessions. While recent studies have demonstrated that a once daily 6-hr bout of EE confers benefits comparable to continuous EE, breaking the therapy into two shorter sessions may increase novelty and ultimately enhance recovery. Hence, the aim of the study was to test the hypothesis that functional and histological outcomes will be significantly improved by daily preclinical neurorehabilitation consisting of two 3-hr periods of EE vs. a single 6-hr session. Anesthetized adult male rats received a controlled cortical impact of moderate-to-severe injury (2.8 mm tissue deformation at 4m/s) or sham surgery and were then randomly assigned to groups receiving standard (STD) housing, a single 6-hr session of EE, or two 3-hr sessions of EE daily for 3 weeks. Motor function (beam-balance/traversal) and acquisition of spatial learning/memory retention (Morris water maze) were assessed on post-operative days 1–5 and 14–19, respectively. Cortical lesion volume was quantified on day 21. Both EE conditions improved motor function and acquisition of spatial learning, and reduced cortical lesion volume relative to STD housing (p < 0.05), but did not differ from one another in any endpoint (p > 0.05). The findings replicate previous work showing that 6-hr of EE daily is sufficient to confer behavioral and histological benefits after TBI and extend the findings by demonstrating that the benefits are comparable regardless of how the 6-hrs of EE are accrued. The relevance of the finding is that it can be extrapolated to the clinic and may benefit patients who cannot endure a single extended period of neurorehabilitation.
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影响因子：
4.2
作者：
Hamm, RJ;Temple, MD;Lyeth, BG
通讯作者：
Lyeth, BG
影响因子：
8.8
作者：
Bayir H;Adelson PD;Wisniewski SR;Shore P;Lai Y;Brown D;Janesko-Feldman KL;Kagan VE;Kochanek PM
通讯作者：
Kochanek PM
影响因子：
4.2
作者：
Cheng, Jeffrey P.;Shaw, Kaitlyn E.;Kline, Anthony E.
通讯作者：
Kline, Anthony E.
影响因子：
6.1
作者：
Hoffman, Ann N.;Cheng, Jeffrey P.;Kline, Anthony E.
通讯作者：
Kline, Anthony E.
影响因子：
1.9
作者：
BLACKERBY W F
通讯作者：
BLACKERBY W F