Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio
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吗啡戒断影响莫里斯水迷宫延迟逃避行为和海马 NR2A/2B 表达比
DOI：
10.1016/j.brainres.2008.02.055
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发表时间：
2008-05
期刊：
影响因子：
2.9
通讯作者：
Luo, Jianhong
中科院分区：
文献类型：
--
作者：
Cao, Jun;Mao, Rongrong;Xu, Tianle;Dong, Zhifang;Xu, Lin;Tian, Meng;Sui, Nan;Zhong, Weixia;Han, Huili;Luo, Jianhong
重复低剂量吗啡治疗促进海马依赖性莫里斯水迷宫的延迟逃避行为，吗啡戒断影响海马 NMDA 受体依赖性突触可塑性。在这里，我们研究了吗啡戒断是否以及如何影响海马突触体的延迟逃避行为和 NR2A/2B 表达比。我们发现延迟逃避行为和 NR2A/2B 表达比均呈现倒 U 型曲线，并在 20 天戒断期内于 4 天戒断时达到峰值。此外，糖皮质激素受体拮抗剂 RU38486 治疗 3 天可将延迟逃避行为和 4 天停药后的 NR2A/2B 比率降低至与 18 小时停药相似的水平。相比之下，高平台应激使18小时戒断的延迟逃避行为达到与4天戒断相似的更高水平，但对NR2A/2B比值没有显着影响。海马内输注 NMDAR 拮抗剂 AP-5 或含有 NR2B 的 NMDAR 拮抗剂 Ro25-6981 3 天后，也发现了类似的行为效应。这些发现表明，重复低剂量吗啡治疗导致的延迟逃避行为可能是一种有用且简单的大鼠模型，用于研究通过压力暴露恢复的成瘾记忆。
Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure.
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影响因子：
2.1
作者：
Jessica D. Payne;L. Nadel;John J.B. Allen;Kevin G.F. Thomas;W. Jacobs
通讯作者：
Jessica D. Payne;L. Nadel;John J.B. Allen;Kevin G.F. Thomas;W. Jacobs
影响因子：
1.7
作者：
Meina Wang;Ya Yang;Zhifang Dong;Jun Cao;Lin Xu
通讯作者：
Meina Wang;Ya Yang;Zhifang Dong;Jun Cao;Lin Xu
阿片戒断改变体内伏核下通路的突触可塑性
影响因子：
3.3
作者：
Dong, Z.;Cao, J.;Xu, L.
通讯作者：
Xu, L.
影响因子：
3.5
作者：
DIAMOND, DM;BENNETT, MC;ROSE, GM
通讯作者：
ROSE, GM
影响因子：
5.3
作者：
Yang, YX;Ma, YM;Xu, L
通讯作者：
Xu, L