A genetic map of Peromyscus with chromosomal assignment of linkage groups (a Peromyscus genetic map).
A genetic map of Peromyscus with chromosomal assignment of linkage groups (a Peromyscus genetic map).
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DOI：
10.1007/s00335-014-9500-8
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发表时间：
2014-04
期刊：
影响因子：
2.5
通讯作者：
Felder, Michael R.
中科院分区：
文献类型：
--
作者：
Kenney-Hunt, Jane;Lewandowski, Adrienne;Glenn, Travis C.;Glenn, Julie L.;Tsyusko, Olga V.;O'Neill, Rachel J.;Brown, Judy;Ramsdell, Clifton M.;Quang Nguyen;Phan, Tony;Shorter, Kimberly R.;Dewey, Michael J.;Szalai, Gabor;Vrana, Paul B.;Felder, Michael R.
啮齿动物属Permyscus是北美数量最多、物种最丰富的哺乳动物群体。该属内自然产生的多样性为研究适应、一夫一妻制、行为和生理表型、生长控制、基因组印记和疾病过程的遗传基础提供了机会。需要更多的基因组资源，包括高质量的遗传图谱，以利用这些机会。我们在草原鹿小鼠(Permyscus Manulatus Bairdii)和老田小鼠(Permyscus Polonotus)之间进行了种间杂交，并在回交后代中记录了减数分裂重组事件。用185个代表常染色体和X染色体的微卫星标记和155个微卫星标记对回交后代进行基因分型，构建了遗传图谱。将构建的遗传图谱与Mus和Rattus的分子图谱进行比较，并考虑到已有的种间互作全染色体作图的结果，可以将大多数连锁群明确地分配到特定的Permyscus染色体上。根据基因组比较，这个Permyscus遗传图谱覆盖了大约83%的家鼠基因组和79%的小鼠基因组。这一图谱支持了先前的结果，即Permyscus基因组与Rattus更相似，而不是Mus。例如，覆盖20只Rattus常染色体和X染色体只需要Permyscus图谱的28个片段，但覆盖19个小鼠常染色体和X染色体需要Permyscus图谱的40个染色体片段。此外，一个Permyscus连锁群对应大约91%的大鼠和76%的小鼠X染色体。
The rodent genus Peromyscus is the most numerous and species rich mammalian group in North America. The naturally occurring diversity within this genus allows opportunities to investigate the genetic basis of adaptation, monogamy, behavioral and physiological phenotypes, growth control, genomic imprinting, and disease processes. Increased genomic resources including a high quality genetic map are needed to capitalize on these opportunities. We produced interspecific hybrids between the prairie deer mouse (Peromyscus maniculatus bairdii) and the oldfield mouse (Peromyscus polionotus) and scored meiotic recombination events in backcross progeny. A genetic map was contructed by genotyping of backcross progeny at 185 gene-based and 155 microsatellite markers representing all autosomes and the X chromosome. Comparison of the constructed genetic map with the molecular maps of Mus and Rattus and consideration of previous results from interspecific reciprocal whole chromosome painting allowed most linkage groups to be unambiguously assigned to specific Peromyscus chromosomes. Based on genomic comparisons, this Peromyscus genetic map covers approximately 83% of the Rattus genome and 79% of the Mus genome. This map supports previous results that the Peromyscus genome is more similar to Rattus than Mus. For example, coverage of the 20 Rattus autosomes and the X chromosome is accomplished with only 28 segments of the Peromyscus map, but coverage of the 19 Mus autosomes and the X chromosome requires 40 chromosomal segments of the Peromyscus map. Furthermore, a single Peromyscus linkage group corresponds to about 91% of the rat and only 76% of the mouse X chromosomes.
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影响因子：
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作者：
Oliver PL;Goodstadt L;Bayes JJ;Birtle Z;Roach KC;Phadnis N;Beatson SA;Lunter G;Malik HS;Ponting CP
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1152/ajpregu.00386.2006
发表时间：
2007-01-01
影响因子：
2.8
作者：
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通讯作者：
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