Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts.
Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts.
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DOI：
10.1016/j.virusres.2016.05.016
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发表时间：
2016-12-02
期刊：
影响因子：
5
通讯作者：
Saif LJ
中科院分区：
文献类型：
--
作者：
Langel SN;Paim FC;Lager KM;Vlasova AN;Saif LJ
对TGEV和PEDV的被动产乳免疫。“肠-乳房-sIgA轴”的诱导。雌性猪伊加浆母细胞从肠道到乳腺的归巢。后备母猪/经产母猪催乳免疫的相关性。预防TGEV和PEDV的母亲疫苗接种策略。新生仔猪肠道疾病引起的发病率、死亡率和生产力损失每年给养猪生产者造成数百万美元的损失。在2013-2014年，猪流行性腹泻病毒（PEDV）爆发导致美国生猪生产商每年损失9亿至18亿美元。被动催乳免疫仍然是保护新生哺乳仔猪免受PEDV等肠道疾病的最有前途和最有效的方法。通过泌乳免疫保护哺乳仔猪依赖于病原体特异性伊加浆母细胞向乳腺的运输和乳汁中分泌型伊加（sIgA）抗体的积累，定义为肠道-乳腺-sIgA轴。由于胎盘的不渗透性，仔猪出生时无丙种球蛋白，并且对过多的传染性病原体高度敏感。它们完全依赖于初乳和乳汁抗体来获得母体催乳免疫。猪传染性胃肠炎病毒（TGEV）是另一种毁灭性的猪传染性胃肠炎病毒，在开发活疫苗和减毒疫苗方面取得了进展，为了解母体免疫和仔猪保护机制提供了新的见解。在这一章中，我们将回顾以往的研究TGEV诱导的催乳免疫提供了一个历史的角度对目前的努力PEDV控制和疫苗在养猪业。鉴定影响泌乳免疫和肠道-乳房-sIgA轴的因素可能导致妊娠猪中PEDV和其他肠道病原体的改进的疫苗方案，并改善整体群体免疫力，猪健康和工业生产力。
Passive Lactogenic Immunity to TGEV and PEDV. Induction of the ‘gut-mammary-sIgA axis’. Homing of IgA plasmablasts from the intestine to the mammary gland in female swine. Correlates of lactogenic immunity in gilts/sows. Maternal Vaccination Strategies to Prevent TGEV and PEDV. Morbidity, mortality, and loss of productivity from enteric diseases in neonatal piglets cost swine producers millions of dollars annually. In 2013–2014, the porcine epidemic diarrhea virus (PEDV) outbreak led to $900 million to $1.8 billion in annual losses to US swine producers. Passive lactogenic immunity remains the most promising and effective way to protect neonatal suckling piglets from enteric diseases like PEDV. Protecting suckling piglets through lactogenic immunity is dependent on trafficking of pathogen-specific IgA plasmablasts to the mammary gland and accumulation of secretory IgA (sIgA) antibodies in milk, defined as the gut-mammary-sIgA axis. Due to an impermeable placenta, piglets are born agammaglobulinic, and are highly susceptible to a plethora of infectious agents. They rely solely on colostrum and milk antibodies for maternal lactogenic immunity. Previous advances in the development of live and attenuated vaccines for another devastating diarrheal virus of pigs, transmissible gastroenteritis virus (TGEV), provide insights into the mechanisms of maternal immunity and piglet protection. In this chapter, we will review previous research on TGEV-induced lactogenic immunity to provide a historical perspective on current efforts for PEDV control and vaccines in the swine industry. Identifying factors that influence lactogenic immunity and the gut-mammary-sIgA axis may lead to improved vaccine regimens for PEDV and other enteric pathogens in gestating swine and improved overall herd immunity, swine health and industry productivity.
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