Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography.
Optical detection of indocyanine green encapsulated biocompatible poly (lactic-co-glycolic) acid nanoparticles with photothermal optical coherence tomography.
复制标题
DOI：
10.1364/ol.37.000981
复制
发表时间：
2012-03-01
期刊：
影响因子：
3.6
通讯作者：
McCarty OJ
中科院分区：
文献类型：
--
作者：
Subhash HM;Xie H;Smith JW;McCarty OJ
We describe a functional imaging paradigm that uses photothermal optical coherence tomography (PT-OCT) to detect indocyanine green (ICG)-encapsulated biocompatible poly(lactic-co-glycolic) acid (PLGA) nanoparticles embedded in highly scattering tissue phantoms with high resolution and sensitivity. The ICG-loaded PLGA nanoparticles were fabricated using a modified emulsification solvent diffusion method. With a 20 kHz axial scan rate, PT-OCT based on spectral-domain interferometric configuration at 1310 nm was used to detect phase changes induced by a 808 nm photothermal excitation of ICG-encapsulated PLGA nanoparticles. An algorithm based on Fourier transform analysis of differential phase of the spectral interferogram was developed for detecting the depth resolved localized photothermal signal. Excellent contrast difference was observed with PT-OCT between phantoms containing different concentrations of ICG-encapsulated PLGA nanoparticles. This technique has the potential to provide simultaneous structural and molecular-targeted imaging with excellent signal-to-noise for various clinical applications.
登录
查看更多内容
影响因子：
5.8
作者：
Saxena, V;Sadoqi, M;Shao, J
通讯作者：
Shao, J
影响因子：
3.6
作者：
Zhou C;Tsai TH;Adler DC;Lee HC;Cohen DW;Mondelblatt A;Wang Y;Connolly JL;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
3.8
作者：
Adler, Desmond C.;Huang, Shu-Wei;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
前哨淋巴结中金纳米棒摄取的三维高分辨率成像。
影响因子：
10.8
作者：
Jung Y;Reif R;Zeng Y;Wang RK
通讯作者：
Wang RK
影响因子：
10.8
作者：
Skala, Melissa C.;Crow, Matthew J.;Izatt, Joseph A.
通讯作者：
Izatt, Joseph A.