Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis.
Age patterns of incidence of geriatric disease in the U.S. elderly population: Medicare-based analysis.
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DOI：
10.1111/j.1532-5415.2011.03786.x
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发表时间：
2012-02
影响因子：
6.3
通讯作者：
Yashin AI
中科院分区：
文献类型：
--
作者：
Akushevich I;Kravchenko J;Ukraintseva S;Arbeev K;Yashin AI
利用医疗保险服务使用文件（MFSU）评估美国老年人群中与衰老相关疾病的发病率模式。使用国家长期护理调查（NLTCS）和监测、流行病学和最终结果（SEER）登记数据（均与MSUF相关，分别为NLTCS-M和SEER-M），使用开发的个体发病日期评估算法，对19种衰老相关疾病的特定发病率进行了评估。在NLTCS中使用了来自整个美国老年人口（医疗保险受益人）的随机样本，SEER登记数据覆盖了26%的美国人口。34，077人来自NLTCS-M，2，154，598人来自SEER-M。使用MFSU中编码的诊断信息、医疗服务/程序日期和Medicare登记/退出信息重建个人病史。大多数疾病（例如，前列腺癌、哮喘、糖尿病）的发病率随年龄单调下降（或在短期增加后下降）。观察到心肌梗死、中风、心力衰竭、溃疡和阿尔茨海默病的发病率随年龄单调增加，随后趋于平稳和下降。肺癌、结肠癌、帕金森氏病和肾功能衰竭的年龄分布呈倒U型。从NLTCS-M和SEER-M获得的结果一致（排除NLTCS-M中循环系统疾病的过量）。敏感性分析证明了评价的发生率的稳定性。开发的计算方法应用于全国代表性的基于医疗保险的数据集，可以在国家一级重建美国老年人口疾病发病率的年龄模式，在系统性偏倚方面具有前所未有的统计准确性和稳定性。
To utilize the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. Age-specific incidence rates of nineteen aging-related diseases were evaluated with the National Long Term Care Survey (NLTCS) and the Surveillance, Epidemiology, and End Results (SEER) Registry data both linked to MSUF (NLTCS-M and SEER-M, respectively), using a developed algorithm for individual date at onset evaluation. A random sample from the entire U.S. elderly population (Medicare beneficiaries) was used in NLTCS, and 26% of U.S. population is covered by the SEER Registry data. 34,077 individuals from NLTCS-M and 2,154,598 from SEER-M. Individual medical histories were reconstructed using information on diagnoses coded in MFSU, dates of medical services/procedures, and Medicare enrollment/disenrollment. The majority of diseases (e.g., prostate cancer, asthma, diabetes) had a monotonic decline (or decline following short period of increase) in incidence with age. A monotonic increase of incidence with age with a subsequent leveling off and decline was observed for myocardial infarction, stroke, heart failure, ulcer, and Alzheimer’s disease. An inverted U-shaped age pattern was detected for lung and colon carcinomas, Parkinson’s disease, and renal failure. The results obtained from the NLTCS-M and SEER-M were in agreement (excluding an excess for circulatory diseases in the NLTCS-M). A sensitivity analysis proved the stability of the evaluated incidence rates. The developed computational approaches applied to the nationally representative Medicare-based datasets allows reconstruction of age patterns of disease incidence in the U.S. elderly population at the national level with unprecedented statistical accuracy and stability with respect to systematic biases.
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影响因子：
5.1
作者：
Gatling, W;Guzder, RN;Mullee, MA
通讯作者：
Mullee, MA
DOI：
10.5402/2011/415790
发表时间：
2011-01-01
期刊：
ISRN oncology
影响因子：
--
作者：
Akushevich, Igor;Kravchenko, Julia;Yashin, Anatoliy
通讯作者：
Yashin, Anatoliy
DOI：
10.1073/pnas.111152298
发表时间：
2001-05-22
影响因子：
11.1
作者：
Manton, KG;Gu, XL
通讯作者：
Gu, XL
影响因子：
--
作者：
Akushevich, Igor;Kravchenko, Julia;Yashin, Anatoliy I.
通讯作者：
Yashin, Anatoliy I.
影响因子：
4.3
作者：
Yashin, Anatoli I.;Akushevich, Igor;Ukraintseva, Svetlana
通讯作者：
Ukraintseva, Svetlana