Changing incidence of hepatitis B and persistent infection risk in adults: a population-based follow-up study from 2011 in China.
Changing incidence of hepatitis B and persistent infection risk in adults: a population-based follow-up study from 2011 in China.
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DOI：
10.1186/s12889-023-15130-y
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发表时间：
2023-02-06
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是在消除病毒性肝炎的背景下，估计中国农村成年人B型肝炎的发病率和慢性风险。自2011年起，示范区每2年开展一次B型肝炎表面抗原（HBsAg）筛查。包括基线HBsAg阴性的个人。发病率计算为HBsAg阳性病例数除以总人次。对HBsAg阳性者随访观察持续感染（> 6个月）、慢性感染（> 12个月）及恢复情况，并检测B肝炎表面抗体（抗-HBs）。进行卡方检验和考克斯比例回归分析。在2，138，532人年中有8，942例事件病例，平均发病率为0.42/100人年。HBV感染率在男女和各年龄组均迅速下降，然后趋于稳定。男性、低人口密度、低人均国内生产总值和岛民与较高的发病率相关。在阳性病例中，4，989例（55.8%）患者接受了随访。持续感染、慢性感染和抗-HBs恢复率分别为32.3%、31.0%和31.4%。持续性或慢性感染在年轻成人和男性中更常见，而血清转化与性别或年龄无关。农村成年居民HBV感染率呈下降趋势，并保持在较低水平。慢性化率相对较高，只有三分之一的人诱导出保护性抗体。应强调对易感人群进行筛查和接种疫苗的重要性。在线版本包含补充材料，可在10.1186/s12889-023-15130-y获得。
This study aimed to estimate hepatitis B incidence and chronicity risk in rural adults in China under the background of eliminating viral hepatitis. Hepatitis B surface antigen (HBsAg) screening was conducted every 2 years in demonstration areas since 2011. Individuals with baseline HBsAg-negative were included. Incidence was calculated as the number of HBsAg-positive cases divided by the total person-times. HBsAg-positive individuals were followed up to study the persistent infection (> 6 months), chronic infection (> 12 months), and recovery with hepatitis B surface antibody (anti-HBs). The chi-square test and cox proportional regression analysis were performed. There were 8,942 incident cases over 2,138,532 person-years, yielding an average incidence of 0.42 per 100 person-years. HBV incidence decreased rapidly in both genders and all age groups and then kept stable. Male gender, low population density, low gross domestic product per capita, and islanders were associated with higher incidence. Of the positive cases, 4,989 (55.8%) patients were followed up. The persistent infection, chronic infection, and recovery with anti-HBs rates were 32.3%, 31.0%, and 31.4%, respectively. Persistent or chronic infection was more common in younger adults and males, while seroconversion had no concern with gender or age. HBV incidence in adult rural residents was decreasing and stayed low. The chronicity rate was relatively high and protective antibodies were induced in only one third. The importance of population-based screening and vaccination for susceptible individuals should be addressed. The online version contains supplementary material available at 10.1186/s12889-023-15130-y.
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影响因子：
3.7
作者：
Msomi N;Naidoo K;Yende-Zuma N;Padayatchi N;Govender K;Singh JA;Abdool-Karim S;Abdool-Karim Q;Mlisana K
通讯作者：
Mlisana K
影响因子：
3.7
作者：
Chen P;Yu C;Ruan B;Yang S;Ren J;Xu W;Luo Z;Li L
通讯作者：
Li L
影响因子：
6.4
作者：
MCMAHON, BJ;ALWARD, WLM;MAYNARD, JE
通讯作者：
MAYNARD, JE
影响因子：
4.2
作者：
Brant, L. J.;Hurrelle, M.;Ramsay, M. E.
通讯作者：
Ramsay, M. E.
影响因子：
12.7
作者：
Suzuki, Y;Kobayashi, M;Kumada, H
通讯作者：
Kumada, H