Prevalence of hepatitis B in insular regions of southeast China: a community-based study.
Prevalence of hepatitis B in insular regions of southeast China: a community-based study.
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DOI：
10.1371/journal.pone.0056444
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Chen P;Yu C;Ruan B;Yang S;Ren J;Xu W;Luo Z;Li L
B型肝炎病毒（HBV）感染仍然是一个重大的公共卫生问题。本研究的目的是调查居住在岛屿地区的人群中HBV的血清流行病学，并为健康规划和监测提供最新的基线数据。在中国舟山和玉环这两个孤岛上进行了一项以社区为基础的横断面调查，没有年龄限制。研究样本采用随机多阶段整群抽样。收集了15878名参与者的血清学样本和人口统计学信息。抗-HBc、B型肝炎病毒表面抗原（HBsAg）和抗-HBs阳性率分别为33.1%、10.4%和56.1%。男性HBV标志物与女性比较差异有统计学意义（P<0.01）。HBV感染率随年龄增长而增加。两岛间HBsAg、抗-HBc阳性率差异有显著性（P<0.01）。丙氨酸氨基转移酶（ALT）水平升高（>38 IU/L）分别在15.6%和7.2%的HBsAg阳性和阴性组。ALT升高男性（12.0%）明显高于女性（5.8%）（P<0.01）。在30岁以上的HBsAg阳性参与者中，甲胎蛋白（AFP）阳性率为0.6%。由于地理位置的原因，我们发现中国东南部岛屿地区的HBV感染率和肝癌发生的可能性仍然很高，远远高于全国的数字。虽然疫苗接种计划在过去20年中一直有效，但政府还应采取一些额外措施来限制B型肝炎的传播。这些措施包括管理高风险人员和居住在岛上的流动人口，扩大免疫人口，并加强对渔民的健康教育。
Hepatitis B virus (HBV) infection remains a significant public health problem. The purpose of this study was to investigate the seroepidemiology of HBV in people living in the insular regions, and to provide the most recent baseline data for planning and monitoring of health. A cross-sectional, community-based survey was conducted without age restriction, on two isolated islands, Zhoushan and Yuhuan, China. The study sample was selected by random multistage cluster sampling. Serological samples and demographic information were collected from 15878 participants. The prevalences of anti-HBV core antibody (anti-HBc), hepatitis B virus surface antigen (HBsAg), and anti-HBV surface antibody (anti-HBs) were 33.1, 10.4, and 56.1%, respectively. We found statistically significant differences of HBV markers in men versus women (P<0.01). The prevalence of HBV infection increased with age. There were significant differences in the rates of HBsAg and anti-HBc positivity between the two islands (P<0.01). Alanine aminotransferase (ALT) levels were elevated (>38 IU/L) in 15.6% and 7.2% of the HBsAg-positive and negative groups, respectively. Elevated ALT levels were significantly higher in males (12.0%) compared with females (5.8%) (P<0.01). The α-fetoprotein (AFP) positivity rate was 0.6% in HBsAg-positive participants over the age of 30. Due to the geographic location, we found that the HBV prevalence and potential for the development of hepatocellular carcinoma remained high in insular regions of southeast China, and are far above the national figures. Although a vaccination program has been in effect over the last 20 years, several additional measures should be adopted by the government to limit the spread of hepatitis B. These include the management of high risk persons and the floating population living on the islands, expansion of the immune population, and increased health education for fisherman.
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婴儿乙型肝炎疫苗接种的有效性及新疫苗接种计划下乙型肝炎病毒流行趋势的预测：大规模调查结果
影响因子：
3.7
作者：
Yang SG;Wang B;Chen P;Yu CB;Deng M;Yao J;Zhu CX;Ren JJ;Wu W;Ju B;Shen JF;Chen Y;Li MD;Ruan B;Li L
通讯作者：
Li L
DOI：
10.1097/meg.0b013e328347322b
发表时间：
2011-08-01
影响因子：
2.1
作者：
Luo, Zhuanbo;Xie, Yirui;Ruan, Bing
通讯作者：
Ruan, Bing
DOI：
10.1016/s0928-4346(96)82012-3
发表时间：
1996-05-01
期刊：
INTERNATIONAL HEPATOLOGY COMMUNICATIONS
影响因子：
--
作者：
Xia, GL;Liu, CB;Qi, XQ
通讯作者：
Qi, XQ
影响因子：
5.5
作者：
André, F
通讯作者：
André, F
DOI：
10.1111/j.1440-1746.2007.05010.x
发表时间：
2007-12-01
影响因子：
4.1
作者：
Nguyen, Van Thi-Thuy;McLaws, Mary-Louise;Dore, Gregory J.
通讯作者：
Dore, Gregory J.