Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.
Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.
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DOI：
10.1016/j.biopsych.2020.06.002
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发表时间：
2021-01-15
影响因子：
10.6
通讯作者：
Alonso MF
中科院分区：
文献类型：
--
作者：
Auerbach RP;Pagliaccio D;Allison GO;Alqueza KL;Alonso MF
自杀想法和行为（STB）或非自杀性自伤（NSSI）没有明确的神经标志物，相对于成年人，青年人的研究更为有限。这一全面的审查重点是磁共振成像（MRI）研究报告的结构和功能神经相关的STB和NSSI在青年：（i）阐明共享和独立的神经变化，（ii）澄清如何发展过程可能与神经变化相互作用，赋予风险，（iii）提供建议的基础上收敛跨研究。共审查了47篇文章（STB = 27; NSSI = 20），值得注意的是，63%的STB文章和45%的NSSI文章是在过去3年中发表的。结构MRI研究表明，在报告STB的青少年中，腹侧前额叶和眶额皮质的体积减小，并且与STB和NSSI相关的前扣带皮质体积减小。关于功能改变，钝纹状体激活可能是STB和NSSI青年的特征，并且在自杀意念者和自杀者中基于任务的额叶边缘连接减少。静息状态功能连接性研究结果强调，自杀未遂者的默认模式网络和显着网络之间的正连接性降低，而自残者则表现出额缘改变。总之，自杀和非自杀行为与自上而下和自下而上的神经改变有关，这可能会损害接近，回避和调节系统。未来的纵向研究，更大的和良好的特征化的样本，特别是那些整合动态压力评估，将很好地定位，以确定新的目标，可能会改善早期识别和治疗的青年与STB和NSSI。
There is no definitive neural marker of suicidal thoughts and behaviors (STB) or non-suicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging (MRI) studies reporting structural and functional neural correlates of STB and NSSI in youth to: (i) elucidate shared and independent neural alternations, (ii) clarify how developmental processes may interact with neural alterations to confer risk, and (iii) provide recommendations based on convergence across studies. Forty-seven articles were reviewed (STB = 27; NSSI = 20), and notably, 63% of STB articles and 45% of NSSI articles were published in the previous 3 years. Structural MRI research suggests reduced volume in the ventral prefrontal and orbitofrontal cortices among youth reporting STB, and there is reduced anterior cingulate cortex volume related to STB and NSSI. With regard to functional alterations, blunted striatal activation may characterize STB and NSSI youth, and there is reduced frontolimbic task-based connectivity in suicide ideators and attempters. Resting state functional connectivity findings highlight reduced positive connectivity between the default mode network and salience network in attempters, and self-injurers exhibit frontolimbic alterations. Together, suicidal and non-suicidal behaviors are related to top-down and bottom-up neural alterations, which may compromise approach, avoidance, and regulatory systems. Future longitudinal research with larger and well-characterized samples, especially those integrating ambulatory stress assessments, will be well-positioned to identify novel targets that may improve early identification and treatment for youth with STB and NSSI.
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影响因子：
3.8
作者：
Auerbach RP;Admon R;Pizzagalli DA
通讯作者：
Pizzagalli DA
DOI：
10.1111/j.1532-7795.2010.00712.x
发表时间：
2011-03-01
期刊：
Journal of research on adolescence : the official journal of the Society for Research on Adolescence
影响因子：
--
作者：
Casey B;Jones RM;Somerville LH
通讯作者：
Somerville LH
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1016/j.jaac.2018.06.036
发表时间：
2019-02-01
影响因子：
13.3
作者：
Alarcon, Gabriela;Sauder, Mitchell;Quevedo, Karina
通讯作者：
Quevedo, Karina
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana