IL-35 expression in hepatocellular carcinoma cells is associated with tumor progression.
IL-35 expression in hepatocellular carcinoma cells is associated with tumor progression.
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肝细胞癌细胞中IL-35的表达与肿瘤进展相关
DOI：
10.18632/oncotarget.10141
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发表时间：
2016-07-19
期刊：
影响因子：
--
通讯作者：
Ding Y
中科院分区：
文献类型：
--
作者：
Long J;Guo H;Cui S;Zhang H;Liu X;Li D;Han Z;Xi L;Kou W;Xu J;Li TS;Ding Y
最近发现IL-35在多种恶性肿瘤的发生发展中起重要作用。我们研究了IL-35在肝细胞癌中的表达及其在肝细胞癌进展中的调控机制。75例肝细胞癌患者的组织芯片显示，IL-35主要定位于癌细胞和癌旁肝细胞的胞浆。定量分析显示，晚期患者IL-35的表达明显低于早期患者。组织学分级越高、肿瘤体积越大、微血管侵犯阳性、有无远处转移和有无淋巴结转移的肝癌患者，IL-35的表达水平越低。IL-35过表达可显著上调HLAABC和CD95，降低MMP2和MMP9的活性，降低细胞的迁移、侵袭和集落形成能力。提示IL-35在肿瘤组织中的表达降低可能参与了肝细胞癌的进展，IL-35有可能成为治疗肝细胞癌的新靶点。
IL-35 has recently been demonstrated to play significant roles in the progression of various malignant tumors. We investigated the expression of IL-35 in hepatocellular carcinoma (HCC) and the regulatory mechanisms in HCC progression. Tissue microarray from 75 HCC patients revealed that IL-35 was primarily localized in the cytoplasm of cancer cells and peri-tumoral hepatocytes. Quantitative analysis showed that IL-35 expression was significantly lower in patients in the advanced stages than in the early stages. Significantly lower expression of IL-35 was also observed in HCC patients with higher histological grades, larger tumor size, positive microvascular invasion and lymph node/distant metastasis. IL-35 over-expression in HepG2 cells significantly upregulated HLA-ABC and CD95, reduced activities of MMP-2 and MMP-9, and decreased cell migration, invasion and colony formation capacities. Our data indicated that decreased expression of IL-35 in tumor tissues might contribute to the progression of HCC, and IL-35 may serve as a new therapeutic target for HCC.
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影响因子：
2.9
作者：
Mittal S;El-Serag HB
通讯作者：
El-Serag HB
影响因子：
5.4
作者：
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
Chua, Kaw Yan
DOI：
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发表时间：
2005-06-01
期刊：
Clinical prostate cancer
影响因子：
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作者：
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通讯作者：
Loberg, Robert
DOI：
10.4049/jimmunol.1100315
发表时间：
2011-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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通讯作者：
Vignali DA