Compromised interhemispheric transfer of information partially mediates cognitive function deficits in adolescents with fetal alcohol syndrome.
Compromised interhemispheric transfer of information partially mediates cognitive function deficits in adolescents with fetal alcohol syndrome.
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DOI：
10.1111/acer.14795
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Jacobson, Sandra W.
中科院分区：
文献类型：
--
作者：
Biffen, Stevie C.;Dodge, Neil C.;Warton, Christopher M. R.;Molteno, Christopher D.;Jacobson, Joseph L.;Meintjes, Ernesta M.;Jacobson, Sandra W.
关键词：
Prenatal alcohol exposure (PAE) has been associated with compromised inter-hemispheric transfer of tactile stimuli in childhood and structural changes to the corpus callosum (CC). In this study we used a finger localization task (FLT) to investigate whether inter-hemispheric transfer deficits persist in adolescence, whether effects of PAE on perceptual reasoning, working memory, and executive function are mediated by deficits in inter-hemispheric transfer of information, and whether CC size in childhood predicts FLT performance in adolescence. Participants were 16- to 17-year-olds from the Cape Town Longitudinal Cohort, whose mothers were recruited during pregnancy and interviewed regarding their alcohol use using the timeline follow-back approach. Diagnoses of fetal alcohol syndrome (FAS) and partial FAS (PFAS) were determined by two expert dysmorphologists; non-syndromal exposed children were designated as heavily exposed (HE); those born to abstainers or light drinkers, as controls. The FLT was administered to 74 participants (12 FAS, 16 PFAS, 14 HE and 32 controls). CC size at age 9–12 years was available for 35 of these participants (7 FAS, 13 PFAS, 5 HE and 10 control). Although degree of PAE was similar in the FAS, PFAS and HE groups, only the adolescents with FAS showed more transfer-related errors than controls in conditions in which one finger was stimulated. FLT performance mediated effects of FAS on perceptual reasoning and executive function. In the subsample for whom neuroimaging data from childhood were available, there was an association among those with PAE of smaller CC volumes with more transfer-related errors on the one-finger/hand hidden condition, suggesting that CC damage previously seen in childhood continues to impact function through adolescence. This study provides evidence of compromised inter-hemispheric transfer of information in adolescents with FAS, while those with PFAS or heavy exposed non-syndromal individuals are apparently spared. It is the first to show that PAE effects on important aspects of cognitive function are partially mediated by deficits in inter-hemispheric transfer of information.
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影响因子：
4.8
作者：
Fan, Jia;Jacobson, Sandra W.;Taylor, Paul A.;Molteno, Christopher D.;Dodge, Neil C.;Stanton, Mark E.;Jacobson, Joseph L.;Meintjes, Ernesta M.
通讯作者：
Meintjes, Ernesta M.
DOI：
10.15288/jsa.1975.36.1154
发表时间：
1975-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
BOWMAN, RS;STEIN, LI;NEWTON, JR
通讯作者：
NEWTON, JR
影响因子：
5.7
作者：
Bookstein, FL;Streissguth, AP;Barr, HM
通讯作者：
Barr, HM
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
5.1
作者：
CLARREN, SK;ALVORD, EC;SMITH, DW
通讯作者：
SMITH, DW