A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.
A continuous-infusion dynamic MRI model at 3.0 Tesla for the serial quantitative evaluation of microvascular proliferation in an animal model of glioblastoma multiforme.
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DOI：
10.1002/mrm.26591
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发表时间：
2017-11
影响因子：
3.3
通讯作者：
Underhill HR
中科院分区：
文献类型：
--
作者：
Underhill HR
目的：建立一种连续灌注的动态磁共振成像技术，用于研究多形性胶质母细胞瘤大鼠脑内肿瘤相关的微血管增殖(MVP)。该模型假定肿瘤相关MVP的影响(如血管通透性、血管内血浆分数)不能单独分离，并求解单个参数(KVSC)，该参数从连续注射造影剂(CA)期间获得的动态图像中量化T1加权对比增强。未治疗的C6荷瘤动物(N=6)在术后第14天和第18天使用3T临床扫描仪进行连续成像，动态空间和时间分辨率分别为0.38×0.38×1.5 mm~3和3.47 S。肿瘤KVSC的中位数(皮尔逊相关系数r=0.94P=0.0052)与CA浓度(根据增强前后的R1图得出的[CA]；r=0.94P=0.0054)之间存在相关性。在POD18，每个肿瘤中的KVSC和[CA]之间存在基于体素的关联(0.45；R<；0.82，P<；0.001)。然而，基于体素的亚区显示KVSC和[CA]之间的关联性降低(N=5；−0.08；R<；0.22，P>；0.05)或相反的关联性(N=1；r=−0.28，P=0.001)，表明肿瘤中血管通透性的位置和随后的CA池之间的差异。持续输注法可为肿瘤相关MVP的定性和监测提供一种定量手段。
To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. The proposed model assumes effects due to tumor-associated MVP (e.g., vascular permeability, Ktrans; intravascular plasma fraction, vp) cannot be individually separated and solves for a single parameter (kvasc) that quantifies the T1-weighted contrast-enhancement from dynamic images acquired during continuous contrast agent (CA) infusion. Untreated C6 tumor-bearing animals (N=6) were serially imaged on post-op days (PODs) 14 and 18 with a 3T clinical scanner utilizing a dynamic spatial and temporal resolution of 0.38×0.38×1.5 mm3 and 3.47 s, respectively. An association was present between PODs 14 and 18 for median tumor kvasc (Pearson’s r=0.94, P=0.0052) and CA concentration ([CA], derived from pre- and post-contrast R1 maps; r=0.94, P=0.0054). On POD 18, there was a voxel-based association between kvasc and [CA] within each tumor (0.45<r<0.82, P<0.001). However, voxel-based sub-regions demonstrated a reduced association between kvasc and [CA] (N=5; −0.08<r< 0.22, P>0.05) or an inverse association (N=1; r= −0.28, P=0.001) indicating differences between locations of vascular permeability and subsequent CA pooling in tumors. The continuous-infusion method may provide a quantitative measure for characterizing and monitoring tumor-associated MVP.
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DOI：
10.1016/j.neurad.2014.02.006
发表时间：
2015-07
期刊：
Journal of neuroradiology = Journal de neuroradiologie
影响因子：
--
作者：
Nicolasjilwan M;Hu Y;Yan C;Meerzaman D;Holder CA;Gutman D;Jain R;Colen R;Rubin DL;Zinn PO;Hwang SN;Raghavan P;Hammoud DA;Scarpace LM;Mikkelsen T;Chen J;Gevaert O;Buetow K;Freymann J;Kirby J;Flanders AE;Wintermark M;TCGA Glioma Phenotype Research Group
通讯作者：
TCGA Glioma Phenotype Research Group
影响因子：
3.5
作者：
Aryal M;Park J;Vykhodtseva N;Zhang YZ;McDannold N
通讯作者：
McDannold N
影响因子：
3.7
作者：
Ng CS;Wei W;Bankson JA;Ravoori MK;Han L;Brammer DW;Klumpp S;Waterton JC;Jackson EF
通讯作者：
Jackson EF
影响因子：
2.6
作者：
Li, KL;Zhu, XP;Jackson, A
通讯作者：
Jackson, A
影响因子：
5.5
作者：
DAVSON, H;SPAZIANI, E
通讯作者：
SPAZIANI, E