Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
Association of Trichomonas vaginalis and cytological abnormalities of the cervix in low risk women.
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DOI：
10.1371/journal.pone.0086266
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Vereecken AJ
中科院分区：
文献类型：
--
作者：
Donders GG;Depuydt CE;Bogers JP;Vereecken AJ
阴道毛滴虫（TV）是子宫颈（癌前）病变发展的诱发因素吗？横断面研究。筛查感染风险低的健康比利时妇女。63,251个连续的宫颈液基样本。实时定量PCR检测TV， 18种HPV类型和巴氏涂片分析细胞学异常。TV和HPV与宫颈发育不良的关系TV DNA的总体患病率为0.37%，低危HPV为2%，高危HPV为13.2%，8.8%有细胞学异常。LR-HPV和HR-HPV与所有细胞学异常均显著相关。TV的存在与LR-和HR-HPV、ASC-US和HSIL相关，但与其他异常无关。所有患有TV和HSIL的女性也患有HR-HPV，而后者仅在患有TV和ASC-US的女性中存在59%。在HPV阴性的女性中，1.3%的ASC-US女性发现TV，但只有0.03%的细胞学正常的女性发现TV （OR 4.2， CL95%为2.1-8.6）。在HR-HPV阳性女性中，TV的存在在一定程度上增加了细胞学异常的可能性（P=0.05），主要是由于ASC-US和LSIL的增加，而不是HSIL的增加。我们得出结论，TV感染与宫颈LR和HR-HPV感染以及ASC-US和HSIL有关。TV是一种伴发性传播感染，但不被认为是导致HSIL和宫颈癌的共同因素。然而，电视可能导致ASC-US的假阳性诊断。
Is Trichomonas vaginalis (TV) an inducing factor for the development of (pre-)cancerous lesions of the cervix? Cross sectional study. Screening healthy Belgian women with low infection risk. 63,251 consecutive liquid based cervical samples. Real time quantitative PCR for presence of TV, 18 HPV types and Pap smear analysis of cytologic abnormalities. Association of TV and HPV with cervix dysplasia The overall prevalence of TV DNA was 0.37%, of low risk HPV 2%, of high risk HPV 13.2%, and 8.8 % had cytological abnormalities. Both LR-HPV and HR-HPV were significantly associated with all cytological abnormalities. Presence of TV was associated with LR- and HR-HPV, ASC-US and HSIL, but not with other abnormalities. All women with TV and HSIL also had HR-HPV, while the latter was present in only 59% of women with TV and ASC-US. Amongst HPV negative women, TV was found in 1.3% of women with ASC-US, but only in 0.03% of women with normal cytology (OR 4.2, CL95% 2.1-8.6). In HR-HPV positive women, presence of TV increased the likelihood of cytological abnormalities somewhat (P=0.05), mainly due to an increase in ASC-US and LSIL, but not HSIL. We conclude that TV infection is associated with both LR and HR-HPV infection of the cervix, as well as with ASC-US and HSIL. TV is a concomitant STI, but is not thought to be a co-factor in the causation of HSIL and cervical cancer. However, TV may cause false positive diagnoses of ASC-US.
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影响因子：
5.3
作者：
Depuydt CE;Boulet GA;Horvath CA;Benoy IH;Vereecken AJ;Bogers JJ
通讯作者：
Bogers JJ
影响因子：
8.8
作者：
Depuydt, CE;Vereecken, AJ;Salembier, GM;Vanbrabant, AS;Boels, LA;van Herck, E;Arbyn, M;Segers, K;Bogers, JJ
通讯作者：
Bogers, JJ
影响因子：
3.1
作者：
Viikki, M;Pukkala, E;Hakama, M
通讯作者：
Hakama, M
影响因子：
2.1
作者：
Depuydt, Christophe E.;Leuridan, Elke;Donders, Gilbert G. G.
通讯作者：
Donders, Gilbert G. G.
影响因子：
9.8
作者：
Lara-Torre, E;Pinkerton, JS
通讯作者：
Pinkerton, JS