Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study.
Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study.
复制标题
DOI：
10.1136/archdischild-2014-307684
复制
发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Boyle EM
中科院分区：
文献类型：
--
作者：
Johnson S;Evans TA;Draper ES;Field DJ;Manktelow BN;Marlow N;Matthews R;Petrou S;Seaton SE;Smith LK;Boyle EM
关于晚期和中度早产（LMPT; 32+0-36+6周）婴儿的神经发育结局的数据很少。本文介绍了LMPT出生后2年结局的前瞻性、基于人群的研究结果。在出生时招募了1130名LMPT和1255名足月出生的儿童。在2岁矫正年龄时，父母完成了一份调查问卷，以评估神经感觉（视觉，听觉，运动）障碍和儿童能力的父母报告-修订，以确定认知障碍。不良结局的相对风险根据性别、社会经济地位和小于胎龄进行调整，并考虑足月多胎妊娠的过度采样进行加权。认知功能障碍的危险因素进行了探讨，使用多变量分析。638名（57%）LMPT婴儿和765名（62%）对照婴儿的父母完成了问卷调查。在LMPT婴儿中，1.6%有感觉神经功能障碍，而对照组为0.3%（RR 4.89，95%CI 1.07至22.25）。认知障碍是最常见的不良结局：LMPT 6.3%;对照组2.4%（RR 2.09，95% CI 1.19 - 3.64）。LMPT婴儿的神经发育障碍风险是正常婴儿的两倍（RR 2.19，95% CI 1.27 - 3.75）。LMPT婴儿认知功能障碍的独立危险因素是男性、社会经济劣势、非白人种族、先兆子痫和出院时未接受母乳。与足月出生的同龄人相比，LMPT婴儿在2岁时患神经发育障碍的风险增加了一倍，大多数障碍发生在认知领域。 男性、社会经济劣势和先兆子痫是LMPT出生后低认知评分的独立预测因素。
There is a paucity of data relating to neurodevelopmental outcomes in infants born late and moderately preterm (LMPT; 32+0–36+6 weeks). This paper present the results of a prospective, population-based study of 2-year outcomes following LMPT birth. 1130 LMPT and 1255 term-born children were recruited at birth. At 2 years corrected age, parents completed a questionnaire to assess neurosensory (vision, hearing, motor) impairments and the Parent Report of Children's Abilities-Revised to identify cognitive impairment. Relative risks for adverse outcomes were adjusted for sex, socio-economic status and small for gestational age, and weighted to account for over-sampling of term-born multiples. Risk factors for cognitive impairment were explored using multivariable analyses. Parents of 638 (57%) LMPT infants and 765 (62%) controls completed questionnaires. Among LMPT infants, 1.6% had neurosensory impairment compared with 0.3% of controls (RR 4.89, 95% CI 1.07 to 22.25). Cognitive impairments were the most common adverse outcome: LMPT 6.3%; controls 2.4% (RR 2.09, 95% CI 1.19 to 3.64). LMPT infants were at twice the risk for neurodevelopmental disability (RR 2.19, 95% CI 1.27 to 3.75). Independent risk factors for cognitive impairment in LMPT infants were male sex, socio-economic disadvantage, non-white ethnicity, preeclampsia and not receiving breast milk at discharge. Compared with term-born peers, LMPT infants are at double the risk for neurodevelopmental disability at 2 years of age, with the majority of impairments observed in the cognitive domain. Male sex, socio-economic disadvantage and preeclampsia are independent predictors of low cognitive scores following LMPT birth.
登录
查看更多内容
影响因子：
8
作者：
Morse, Steven Benjamin;Zheng, Hao;Roth, Jeffrey
通讯作者：
Roth, Jeffrey
影响因子：
--
作者：
Gurka, Matthew J.;LoCasale-Crouch, Jennifer;Blackman, James A.
通讯作者：
Blackman, James A.
出生时胎龄对3岁和5岁时健康结果的影响：基于人群的队列研究。
DOI：
10.1136/bmj.e896
发表时间：
2012-03-01
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Boyle EM;Poulsen G;Field DJ;Kurinczuk JJ;Wolke D;Alfirevic Z;Quigley MA
通讯作者：
Quigley MA
影响因子：
9.8
作者：
Lipkind, Heather S.;Slopen, Meredith E.;McVeigh, Katharine H.
通讯作者：
McVeigh, Katharine H.
影响因子：
5.1
作者：
Chyi, Lisa J.;Lee, Henry C.;Sutcliffe, Trenna L.
通讯作者：
Sutcliffe, Trenna L.