Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice.
Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice.
复制标题
酸性活性炭可预防高脂饮食喂养小鼠的肥胖和胰岛素抵抗。
DOI：
10.3389/fnut.2022.852767
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发表时间：
2022
影响因子：
5
通讯作者：
Tanaka, Naoki
中科院分区：
文献类型：
--
作者：
Zhang, Xuguang;Diao, Pan;Yokoyama, Hiroaki;Inoue, Yoshiki;Tanabe, Kazuhiro;Wang, Xiaojing;Hayashi, Chihiro;Yokoyama, Tomoki;Zhang, Zhe;Hu, Xiao;Nakajima, Takero;Kimura, Takefumi;Nakayama, Jun;Nakamuta, Makoto;Tanaka, Naoki
关键词：
肥胖症正在成为世界范围内的一个主要公共卫生问题。用木材制作木炭（“Sumi-yaki”）是长野县南部几个世纪以来的传统活动，活性炭具有解毒效果。然而，目前尚不清楚活性炭是否也具有抗肥胖特性。此外，由于活性炭通常是碱性的，可能会受到胃液的影响，我们评估了酸性活性炭对高脂饮食（HFD）诱导的肥胖的影响。该研究表明，酸性活性炭与HFD的共同治疗以剂量依赖性方式显著改善了小鼠的肥胖和胰岛素抵抗。盲肠内容物的代谢组学分析表明，中性脂质，胆固醇和胆汁酸排泄在粪便中的活性炭治疗显着较高的水平。此外，肝脏表达的基因编码胆固醇7 α-羟化酶和羟甲基戊二酰辅酶A还原酶/合成酶1活性炭上调，可能反映了增强的排泄从肠道和肠肝循环的胆固醇和胆汁酸。在胃肠道、肝脏、胰腺和肺中未检测到损伤或异常。总之，酸性活性炭可能能够减轻HFD诱导的体重增加和胰岛素抵抗，而不会产生严重的不良反应。这些发现表明木炭具有预防肥胖、代谢综合征和相关疾病的新功能。
Obesity is becoming a major public health problem worldwide. Making charcoal from wood (“Sumi-yaki”) has been a traditional activity in the southern part of Nagano Prefecture for centuries, with activated charcoal having reported detoxifying effects. However, it is unclear whether activated charcoal also possesses anti-obesity properties. Additionally, since activated charcoal is usually alkaline and might be affected by gastric juice, we evaluated the effect of acidic activated charcoal on high-fat diet (HFD)-induced obesity. This study demonstrated that co-treatment of acidic activated charcoal with a HFD significantly improved obesity and insulin resistance in mice in a dose-dependent manner. Metabolomic analysis of cecal contents revealed that neutral lipids, cholesterol, and bile acids were excreted at markedly higher levels in feces with charcoal treatment. Moreover, the hepatic expressions of genes encoding cholesterol 7 alpha-hydroxylase and hydroxymethylglutaryl-CoA reductase/synthase 1 were up-regulated by activated charcoal, likely reflecting the enhanced excretions from the intestine and the enterohepatic circulation of cholesterol and bile acids. No damage or abnormalities were detected in the gastrointestinal tract, liver, pancreas, and lung. In conclusion, acidic activated charcoal may be able to attenuate HFD-induced weight gain and insulin resistance without serious adverse effects. These findings indicate a novel function of charcoal to prevent obesity, metabolic syndrome, and related diseases.
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DOI：
10.1016/j.bbalip.2014.08.015
发表时间：
2014-11
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Tanaka N;Takahashi S;Fang ZZ;Matsubara T;Krausz KW;Qu A;Gonzalez FJ
通讯作者：
Gonzalez FJ
影响因子：
5.8
作者：
Vicens, Marta;Macias, Rocio I. R.;Marin, Jose J. G.
通讯作者：
Marin, Jose J. G.
影响因子：
5.6
作者：
Yang, Jieping;Zhang, Song;Li, Zhaoping
通讯作者：
Li, Zhaoping
DOI：
10.3390/molecules21030313
发表时间：
2016-03-05
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Huang WC;Lin CL;Hsu YJ;Chiu YS;Chen YM;Wu MF;Huang CC;Wang MF
通讯作者：
Wang MF
影响因子：
3.5
作者：
Huber, M.;Pohl, W.;Lintner, F.
通讯作者：
Lintner, F.