Changes in serum concentrations of maternal poly- and perfluoroalkyl substances over the course of pregnancy and predictors of exposure in a multiethnic cohort of Cincinnati, Ohio pregnant women during 2003-2006.
Changes in serum concentrations of maternal poly- and perfluoroalkyl substances over the course of pregnancy and predictors of exposure in a multiethnic cohort of Cincinnati, Ohio pregnant women during 2003-2006.
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DOI：
10.1021/es501811k
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发表时间：
2014-08-19
影响因子：
11.4
通讯作者：
Calafat, Antonia M.
中科院分区：
文献类型：
--
作者：
Kato, Kayoko;Wong, Lee-Yang;Chen, Aimin;Dunbar, Carmen;Webster, Glenys M.;Lanphear, Bruce P.;Calafat, Antonia M.
在美国，孕期接触多氟烷基物质和全氟烷基物质(PFAS)的预测因素的数据是有限的。为了填补这一空白，在2003年至2006年招募的俄亥俄州多民族孕妇队列中，我们检测了妊娠16周(N=182)和分娩(N=78)时∼孕妇血清中的全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)和另外6种PFASs，以及脐带血清(N=202)。我们使用线性回归来检验母体血清PFASs浓度与人口统计学、围产期和生活方式因素之间的关系。孕妇血清和婴儿脐带血清中PFASs浓度高度相关(Spearman等级相关系数=0.73~0.95)。71对母婴分娩时母体血清未经调整的几何平均(GM)浓度(95%可信区间)(μg/L)分别为8.5(7.01-9.58)和3.43(3.01-3.90)，显著低于16周时的11.57(9.90-13.53)和4.91(4.32-5.59)，但高于新生儿脐血[3.32(2.84-3.89)，P<0.05]。2.85(2.51-3.24)，(P<；0.001)。有过哺乳史、黑人或处于最低收入类别的产妇的全氟辛烷磺酸和全氟辛烷磺酸GM浓度显著低于其他妇女。这些数据表明，在美国出生队列中，首次在怀孕和哺乳期间通过胎盘转移PFASs。
Data on predictors of gestational exposure to poly- and perfluoroalkyl substances (PFASs) in the United States are limited. To fill in this gap, in a multiethnic cohort of Ohio pregnant women recruited in 2003–2006, we measured perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and six additional PFASs in maternal serum at ∼16 weeks gestation (N = 182) and delivery (N = 78), and in umbilical cord serum (N = 202). We used linear regression to examine associations between maternal serum PFASs concentrations and demographic, perinatal, and lifestyle factors. PFASs concentrations in maternal sera and in their infants’ cord sera were highly correlated (Spearman rank correlation coefficients = 0.73–0.95). In 71 maternal-infant dyads, unadjusted geometric mean (GM) concentrations (95% confidence interval) (in μg/L) in maternal serum at delivery of PFOS [8.50 (7.01–9.58)] and PFOA [3.43 (3.01–3.90)] were significantly lower than at 16 weeks gestation [11.57 (9.90–13.53], 4.91 (4.32–5.59), respectively], but higher than in infants’ cord serum [3.32 (2.84–3.89), 2.85 (2.51–3.24), respectively] (P < 0.001). Women who were parous, with a history of previous breastfeeding, black, or in the lowest income category had significantly lower PFOS and PFOA GM concentrations than other women. These data suggest transplacental transfer of PFASs during pregnancy and nursing for the first time in a U.S. birth cohort.
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影响因子：
5.6
作者：
Costantine MM
通讯作者：
Costantine MM
影响因子：
11.8
作者：
Christensen KY;Maisonet M;Rubin C;Holmes A;Calafat AM;Kato K;Flanders WD;Heron J;McGeehin MA;Marcus M
通讯作者：
Marcus M
影响因子：
11.4
作者：
Eriksen, Kirsten T.;Sorensen, Mette;Raaschou-Nielsen, Ole
通讯作者：
Raaschou-Nielsen, Ole
影响因子：
10.4
作者：
Hernick AD;Brown MK;Pinney SM;Biro FM;Ball KM;Bornschein RL
通讯作者：
Bornschein RL
影响因子：
11.4
作者：
Fromme, Hermann;Mosch, Christine;Volkel, Wolfgang
通讯作者：
Volkel, Wolfgang