The disease burden of pertussis in adults 50 years old and older in the United States: a retrospective study.
The disease burden of pertussis in adults 50 years old and older in the United States: a retrospective study.
复制标题
DOI：
10.1186/1471-2334-13-32
复制
发表时间：
2013-01-23
影响因子：
3.7
通讯作者：
Krishnarajah G
中科院分区：
文献类型：
--
作者：
McGuiness CB;Hill J;Fonseca E;Hess G;Hitchcock W;Krishnarajah G
虽然近年来美国青少年和成年人的百日咳发病率有所增加，但对老年人百日咳的发病率和经济负担知之甚少。这项研究提供了美国50岁及以上成年人百日咳发病率和与百日咳护理事件( )相关的直接医疗费用的证据。百日咳护理事件(PEOC)被分为初始百日咳诊断之前和之后(即指数日期)的时期，以记录在百日咳诊断之前可能代表误诊的任何情况以及可能代表后遗症的后续情况。数据摘录自IMS最近获得的纵向、患者级从业者索赔和医院运营账单记录的SDI数据库，分别从全美私人执业医生和医院收集。50岁及以上、在2006年1月1日至2010年10月31日期间一次或多次 -9-CM诊断为百日咳/百日咳和/或实验室检测为百日咳阳性的患者符合纳入研究的条件。分析了与患者的医生和医院护理相关的资源利用和费用(即，未裁决的索赔)。全国预测的百日咳发病率是使用具有预测所需数据的患者子样本来估计的。2006年至2010年，经诊断的百日咳发病率在两个年龄组(50岁至和[大于或等于]65岁)的每100,000人中估计为2.1-4.6例。费用分析包括5,748名年龄[大于或等于]50 的百日咳患者。在整个护理过程中，门诊和住院患者的平均费用分别为1,835美元和14,428美元。在指数化前和指数期后，门诊(即私人执业医生)的平均就诊次数为每名患者2次。在美国，50 及以上成年人确诊为百日咳的发病率在2006年至2010年间有所上升。与百日咳相关的医疗保健利用率和收费很高，这表明需要额外的预防和控制战略，以及卫生保健提供者更高程度的临床意识。需要对老年人群中的百日咳进行更多的研究来证实这些发现。
While the incidence of pertussis has increased in adolescents and adults in recent years in the U.S., little is known about the incidence and economic burden of pertussis in older adults. This study provides evidence of the incidence of pertussis and direct medical charges associated with pertussis episodes of care (PEOCs) in adults aged 50 years and older in the U.S. PEOCs were divided into periods before and after the initial pertussis diagnosis was made (i.e., the index date) to capture any conditions immediately preceding the pertussis diagnosis that may have represented misdiagnoses and subsequent conditions that may have represented sequelae. Data were extracted from IMS's recently acquired SDI databases of longitudinal, patient-level practitioner claims and hospital operational billing records collected from private practitioners and hospitals, respectively, across the U.S. Patients 50 years and older with one or more ICD-9-CM diagnoses for pertussis/whooping cough and/or a laboratory test positive for Bordetella pertussis between 1/1/2006 and 10/31/2010 were eligible for study inclusion. Resource utilization and charges (i.e., unadjudicated claims) associated with the patient's physician and hospital care were analyzed. The nationally projected incidence of pertussis was estimated using a subsample of patients with the required data necessary for projection. Estimated incidence of diagnosed pertussis ranged from 2.1-4.6 cases per 100,000 people across the two age groups (50–64 and [greater than or equal to] 65) during the years 2006 to 2010. The analysis of charges included 5,748 patients [greater than or equal to] 50 years of age with pertussis. Average charges across the entire episode of care were $1,835 and $14,428 per patient in the outpatient and inpatient settings, respectively. The average number of outpatient (i.e., private practitioner) visits was 2 per patient in both the pre-index and post-index periods. In the U.S., the incidence of diagnosed pertussis in adults 50 years and older has increased between 2006 and 2010. Healthcare utilization and charges associated with pertussis are substantial, suggesting the need for additional prevention and control strategies and a higher degree of clinical awareness on the part of health care providers. Additional research regarding pertussis in older populations is needed to substantiate these findings.
登录
查看更多内容
影响因子：
11.8
作者：
Lee, GM;Lett, S;Lieu, TA
通讯作者：
Lieu, TA
影响因子：
105.7
作者：
JENKINSON, D
通讯作者：
JENKINSON, D
DOI：
10.1097/01.inf.0000160708.43944.99
发表时间：
2005-05-01
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Tan, Tina;Trindade, Evelinda;Skowronski, Danuta
通讯作者：
Skowronski, Danuta
影响因子：
--
作者：
Hong, Jung Yun
通讯作者：
Hong, Jung Yun
影响因子：
11.8
作者：
G端ris, D;Strebel, PM;Livengood, JR
通讯作者：
Livengood, JR