Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.
Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories.
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DOI：
10.1016/j.cmet.2018.08.011
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发表时间：
2019-01-08
期刊：
影响因子：
29
通讯作者：
de Cabo R
中科院分区：
文献类型：
--
作者：
Mitchell SJ;Bernier M;Mattison JA;Aon MA;Kaiser TA;Anson RM;Ikeno Y;Anderson RM;Ingram DK;de Cabo R
食物组成和喂养方式在衰老过程中的重要性在很大程度上仍未得到探索，但最近在两项重要的非人类灵长类动物研究中发现了这一点。在这里，我们在小鼠身上直接比较了灵长类研究中使用的两种饮食，重点放在三种范例上：自由饮食(AL)、30%卡路里限制(CR)和单餐喂养(MF)，这说明了AL小鼠消耗的能量密度和卡路里摄入量的差异。无论饮食结构如何，MF和CR方案都能延长寿命，这在喂养方案中单独没有显著影响。与CR动物一样，MF小鼠进食迅速，每天延长禁食时间，与AL相比，发病率和死亡率都有显著改善。这些通过延长每日禁食时间而带来的健康和生存益处与饮食构成无关，对人类健康和临床适用性具有重大影响。Mitchell等人。结果表明，无论卡路里摄入量、饮食组成和体重如何，长时间的每日禁食都能改善雄性小鼠的健康和存活率。
The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and a single meal feeding (MF) that accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared to AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability. Mitchell et al. show that a long daily period of fasting improves the health and survival of male mice, regardless of caloric intake, diet composition, and bodyweight.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
64.8
作者：
Mattison, Julie A.;Roth, George S.;Beasley, T. Mark;Tilmont, Edward M.;Handy, April M.;Herbert, Richard L.;Longo, Dan L.;Allison, David B.;Young, Jennifer E.;Bryant, Mark;Barnard, Dennis;Ward, Walter F.;Qi, Wenbo;Ingram, Donald K.;de Cabo, Rafael
通讯作者：
de Cabo, Rafael
影响因子：
5.9
作者：
Mustonen AM;Kärjä V;Kilpiö M;Tammi R;Tammi M;Rouvinen-Watt K;Halonen T;Nieminen P
通讯作者：
Nieminen P
影响因子：
64.5
作者：
de Cabo R;Carmona-Gutierrez D;Bernier M;Hall MN;Madeo F
通讯作者：
Madeo F
影响因子：
82.9
作者：
Kaushik, Susmita;Cuervo, Ana Maria
通讯作者：
Cuervo, Ana Maria