Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis.
Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis.
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DOI：
10.1155/2015/718329
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发表时间：
2015
影响因子：
4.6
通讯作者：
Camici PG
中科院分区：
文献类型：
--
作者：
Ammirati E;Moroni F;Norata GD;Magnoni M;Camici PG
动脉粥样硬化是影响大中动脉的全身性疾病的局灶性表现，传统的心血管危险因素和免疫因素在其中发挥着关键作用。人们普遍认为，包括 C 反应蛋白和白细胞介素 6 在内的循环生物标志物可以可靠地预测主要心血管事件，包括心肌梗塞或死亡。然而，全身炎症生物标志物与颈动脉粥样硬化进展的相关性尚不明确。绝大多数临床研究集中在生物标志物与亚临床动脉粥样硬化（即颈动脉内膜中层增厚（cIMT））之间的关联，这代表了该疾病的早期阶段。这项工作的目的是回顾与颈动脉粥样硬化斑块患者中较高的动脉粥样硬化负担、较快的疾病进展以及斑块不稳定特征（例如炎症或新生血管形成）相关的炎症生物标志物，与 cIMT 相比，颈动脉粥样硬化斑块代表疾病的晚期阶段。还将介绍生物标志物与继发于颈动脉斑块破裂的脑血管事件发生的关联。目前，颈动脉狭窄程度用于预测颈动脉粥样硬化患者未来发生脑血管事件的风险。然而，这种策略似乎并不理想。合适的生物标志物的识别可以提供有用的辅助标准，以确保更好的风险分层和优化管理。
Atherosclerosis is the focal expression of a systemic disease affecting medium- and large-sized arteries, in which traditional cardiovascular risk factor and immune factors play a key role. It is well accepted that circulating biomarkers, including C-reactive protein and interleukin-6, reliably predict major cardiovascular events, including myocardial infarction or death. However, the relevance of biomarkers of systemic inflammation to atherosclerosis progression in the carotid artery is less established. The large majority of clinical studies focused on the association between biomarkers and subclinical atherosclerosis, that is, carotid intima-media thickening (cIMT), which represents an earlier stage of the disease. The aim of this work is to review inflammatory biomarkers that were associated with a higher atherosclerotic burden, a faster disease progression, and features of plaque instability, such as inflammation or neovascularization, in patients with carotid atherosclerotic plaque, which represents an advanced stage of disease compared with cIMT. The association of biomarkers with the occurrence of cerebrovascular events, secondary to carotid plaque rupture, will also be presented. Currently, the degree of carotid artery stenosis is used to predict the risk of future cerebrovascular events in patients affected by carotid atherosclerosis. However, this strategy appears suboptimal. The identification of suitable biomarkers could provide a useful adjunctive criterion to ensure better risk stratification and optimize management.
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影响因子：
1.9
作者：
Andersson, Jessika;Sundstrom, Johan;Lind, Lars
通讯作者：
Lind, Lars
影响因子：
8.3
作者：
de Weerd M;Greving JP;Hedblad B;Lorenz MW;Mathiesen EB;O'Leary DH;Rosvall M;Sitzer M;Buskens E;Bots ML
通讯作者：
Bots ML
影响因子：
3.7
作者：
Abbas A;Aukrust P;Russell D;Krohg-Sørensen K;Almås T;Bundgaard D;Bjerkeli V;Sagen EL;Michelsen AE;Dahl TB;Holm S;Ueland T;Skjelland M;Halvorsen B
通讯作者：
Halvorsen B
影响因子：
24
作者：
Corti, R;Fuster, V;Badimon, JJ
通讯作者：
Badimon, JJ
影响因子：
37.8
作者：
Davis, PH;Dawson, JD;Lauer, RM
通讯作者：
Lauer, RM