Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines.
Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines.
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用于探索纳米药物的生物学行为和命运的先进光源分析技术
DOI：
10.1021/acscentsci.2c00680
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发表时间：
2022-08-24
影响因子：
18.2
通讯作者：
Chen, Chunying
中科院分区：
文献类型：
--
作者：
Cao, Mingjing;Zhang, Kai;Zhang, Shuhan;Wang, Yaling;Chen, Chunying
受纳米材料-生物学（纳米生物）相互作用影响的纳米颗粒的生物学行为和命运的探索，对于指导纳米药物的合理设计和优化，以最大限度地减少不良反应，支持临床转化，并帮助监管机构进行评估，已经变得越来越重要。由于生物环境的复杂性和纳米药物生物活性的动态变化，原位、无标记分析纳米药物的转运和转化仍然是一个挑战。光学，探测器和光源的最新改进使得先进光源（ALS）分析技术得以扩展，以深入研究纳米药物在体内未被探索的行为和命运。进一步发展具有更高时空分辨率、多模态数据融合和智能预测能力的基于als的分析技术，以充分释放纳米药物的潜力变得越来越重要。在本展望中，我们将重点介绍几种精选的ALS分析技术，包括成像和光谱学，并概述了它们在探索纳米药物的生物行为和命运方面的新应用机会。我们还讨论了当前方法和工具所面临的挑战和局限性，以及对未来先进光源和技术发展的期望。改进的ALS成像和光谱技术将加速对新型纳米药物的生物学行为的深刻理解。这些进展有望激发纳米医学研究的新见解，并促进ALS更适合纳米医学评估的能力和方法的发展，以临床转化为目标。作为无标签和原位分析方法，先进的基于光源的技术，包括显微镜和光谱学，在探索纳米药物的生物行为和命运方面具有巨大的潜力。
Exploration of the biological behavior and fate of nanoparticles, as affected by the nanomaterial–biology (nano–bio) interaction, has become progressively critical for guiding the rational design and optimization of nanomedicines to minimize adverse effects, support clinical translation, and aid in evaluation by regulatory agencies. Because of the complexity of the biological environment and the dynamic variations in the bioactivity of nanomedicines, in-situ, label-free analysis of the transport and transformation of nanomedicines has remained a challenge. Recent improvements in optics, detectors, and light sources have allowed the expansion of advanced light source (ALS) analytical technologies to dig into the underexplored behavior and fate of nanomedicines in vivo. It is increasingly important to further develop ALS-based analytical technologies with higher spatial and temporal resolution, multimodal data fusion, and intelligent prediction abilities to fully unlock the potential of nanomedicines. In this Outlook, we focus on several selected ALS analytical technologies, including imaging and spectroscopy, and provide an overview of the emerging opportunities for their applications in the exploration of the biological behavior and fate of nanomedicines. We also discuss the challenges and limitations faced by current approaches and tools and the expectations for the future development of advanced light sources and technologies. Improved ALS imaging and spectroscopy techniques will accelerate a profound understanding of the biological behavior of new nanomedicines. Such advancements are expected to inspire new insights into nanomedicine research and promote the development of ALS capabilities and methods more suitable for nanomedicine evaluation with the goal of clinical translation. As label-free and in-situ analytical methods, advanced light source-based technologies, including microscopy and spectroscopy, hold great potential for exploring the biological behavior and fate of nanomedicines.
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具有冷冻和X射线的中尺度成像：比分子机大，比单元小。
影响因子：
2.7
作者：
Ekman AA;Chen JH;Guo J;McDermott G;Le Gros MA;Larabell CA
通讯作者：
Larabell CA
影响因子：
17.1
作者：
Bao, Lin;Cui, Xuejing;Chen, Chunying
通讯作者：
Chen, Chunying
影响因子：
4.6
作者：
Chien, Chia-Chi;Chen, Hsiang-Hsin;Lai, Sheng-Feng;Hwu, Y.;Petibois, Cyril;Yang, C. S.;Chu, Y.;Margaritondo, G.
通讯作者：
Margaritondo, G.
影响因子：
3.5
作者：
Bai, Ru;Zhang, Lili;Chen, Chunying
通讯作者：
Chen, Chunying
DOI：
10.1073/pnas.1413003112
发表时间：
2015-02-24
影响因子：
11.1
作者：
Deng, Junjing;Vine, David J.;Jacobsen, Chris J.
通讯作者：
Jacobsen, Chris J.