MicroRNAs in the regulation of Th17/Treg homeostasis and their potential role in uveitis.
MicroRNAs in the regulation of Th17/Treg homeostasis and their potential role in uveitis.
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DOI：
10.3389/fgene.2022.848985
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发表时间：
2022
影响因子：
3.7
通讯作者：
Xu, Fan
中科院分区：
文献类型：
--
作者：
Tang, Fen;Zhou, Zhou;Huang, Kongqian;Deng, Wen;Lin, Jiali;Chen, Ruoyun;Li, Min;Xu, Fan
Th 17和调节性T细胞（Treg）在自身免疫性疾病的发病机制中起着至关重要的作用。Th 17/Treg稳态在维持免疫平衡中起关键作用。Th 17/Treg稳态失调会导致自身免疫性疾病的进展。microRNA（miRNAs）已成为调节Th 17/Treg稳态紊乱的一个新的重要因素。为了更好地了解miRNAs调控Treg/Th 17稳态的表观遗传学机制，我们对97篇自身免疫性疾病相关文献进行了检索和评价，发现miRNAs在调节Treg/Th 17稳态方面发挥了积极或消极的作用，包括Treg分化发育、Treg诱导、Treg稳定性、Th 17分化和Treg功能。葡萄膜炎是一种眼部自身免疫性疾病，其特征也是Th 17/Treg失衡。然而，我们对葡萄膜炎发病机制中的miRNAs的理解是难以捉摸的，并且没有得到很好的研究。本文就自身免疫性葡萄膜炎相关miRNAs及其在调节Th 17/Treg稳态中的作用作一综述。
Th17 and regulatory T cells (Tregs) play crucial roles in the pathogenesis of autoimmune diseases. Th17/Treg homeostasis is critically involved in maintaining the immune balance. Disturbed Th17/Treg homeostasis contributes to the progression of autoimmune diseases. MicroRNAs (miRNAs) have emerged as a new vital factor in the regulation of disturbed Th17/Treg homeostasis. To better understand the epigenetic mechanisms of miRNAs in regulating Treg/Th17 homeostasis, we included and evaluated 97 articles about autoimmune diseases and found that miRNAs were involved in the regulation of Treg/Th17 homeostasis from several aspects positively or negatively, including Treg differentiation and development, Treg induction, Treg stability, Th17 differentiation, and Treg function. Uveitis is one of the ocular autoimmune diseases, which is also characterized with Th17/Treg imbalance. However, our understanding of the miRNAs in the pathogenesis of uveitis is elusive and not well-studied. In this review, we further summarized miRNAs found to be involved in autoimmune uveitis and their potential role in the regulation of Th17/Treg homeostasis.
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DOI：
10.1084/jem.20061692
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Merkenschlager M
影响因子：
7.3
作者：
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通讯作者：
Blazar BR
影响因子：
30.5
作者：
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通讯作者：
Pei, Gang
影响因子：
6
作者：
Ha TY
通讯作者：
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DOI：
10.2147/opth.s94866
发表时间：
2016
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
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通讯作者：
Tomkins-Netzer O