Methodological challenges in the comparison of infant fMRI across age groups.
Methodological challenges in the comparison of infant fMRI across age groups.
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DOI：
10.1016/j.dcn.2017.11.003
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发表时间：
2018-10
影响因子：
4.7
通讯作者：
Linke AC
中科院分区：
文献类型：
--
作者：
Cusack R;McCuaig O;Linke AC
婴儿的功能性MRI（fMRI）正在迅速发展，并提供了对大脑功能起源的基本见解。比较不同年龄的大脑发育特别有效，但如果要避免混淆，必须解决一些方法上的挑战。随着发育，大脑的组成发生变化，从而改变其组织对比度，以及大小，形状和旋转，需要仔细的图像处理策略和特定年龄的标准模板。血流动力学反应和生理学的其他方面随年龄变化，需要仔细的范式设计和分析方法。婴儿移动更多，特别是在2岁左右，并且移动方式与成人不同。这种运动会导致fMRI图像失真，需要在采集和后处理过程中采用定制技术。婴儿有不同的睡眠模式，他们的感觉周围正在发生变化，宏观和神经通路。最后，一旦数据被获取和分析，在绘制不同年龄组的大脑过程和认知功能时，有一些重要的考虑因素。总之，新方法对于跨年龄组的比较至关重要，也是最大限度地提高婴儿功能磁共振成像（fMRI）对认知起源这一迷人问题的洞察力的关键。
Functional MRI (fMRI) in infants is rapidly growing and providing fundamental insights into the origins of brain functions. Comparing brain development at different ages is particularly powerful, but there are a number of methodological challenges that must be addressed if confounds are to be avoided. With development, brains change in composition in a way that alters their tissue contrast, and in size, shape, and gyrification, requiring careful image processing strategies and age-specific standard templates. The hemodynamic response and other aspects of physiology change with age, requiring careful paradigm design and analysis methods. Infants move more, particularly around the second year of age, and move in a different way to adults. This movement can lead to distortion in fMRI images, and requires tailored techniques during acquisition and post-processing. Infants have different sleep patterns, and their sensory periphery is changing macroscopically and in its neural pathways. Finally, once data have been acquired and analyzed, there are important considerations during mapping of brain processes and cognitive functions across age groups. In summary, new methods are critical to the comparison across age groups, and key to maximizing the rate at which infant fMRI can provide insight into the fascinating questions about the origin of cognition.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
2.5
作者：
Anderson, AW;Marois, R;Ment, LR
通讯作者：
Ment, LR
影响因子：
5.7
作者：
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通讯作者：
D'Esposito, M
影响因子：
2.8
作者：
Arichi, T.;Counsell, S. J.;Edwards, A. D.
通讯作者：
Edwards, A. D.
影响因子：
5.7
作者：
Altaye, Mekibib;Holland, Scott K.;Wilke, Marko;Gaser, Christian
通讯作者：
Gaser, Christian