Enhanced survival from radiation pneumonitis by combined irradiation to the skin.
Enhanced survival from radiation pneumonitis by combined irradiation to the skin.
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DOI：
10.3109/09553002.2014.922722
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发表时间：
2014-09
影响因子：
2.6
通讯作者：
Medhora M
中科院分区：
文献类型：
--
作者：
Gao F;Fish BL;Szabo A;Schock A;Narayanan J;Jacobs ER;Moulder JE;Lazarova Z;Medhora M
开发肺和皮肤联合照射的缓解剂。X射线治疗大鼠如下：（1）12.5或13戈伊全胸照射（WTI）（2）30戈伊软X射线仅照射10%的皮肤面积（3）12.5或13戈伊WTI+30戈伊皮肤照射3小时后（4）12.5戈伊WTI+皮肤照射，并在7天后开始用卡托普利（160 mg/m2/天）治疗。我们的终点是基于IACUC安乐死标准的生存（主要）和呼吸间隔和皮肤损伤的次要测量。在13戈伊WTI存活的大鼠中测量210天时的肺胶原。在12.5戈伊WTI（有或无皮肤照射）后，对1只大鼠（12.5戈伊WTI）实施安乐死。接受13戈伊剂量WTI的大鼠存活率低于10%，但与皮肤照射结合使用时，存活率有所提高（p<0.0001）。13戈伊WTI照射后210天胶原含量比13戈伊WTI+30戈伊皮肤照射后增加（p<0.05）。在12.5戈伊WTI+30戈伊皮肤照射后，卡托普利改善了放射性皮炎（p=0.008）。WTI后3小时给予皮肤辐射减轻了大鼠肺炎期间的发病率。开搏通可提高胸部和皮肤联合照射后放射性皮炎的愈合率。
To develop mitigators for combined irradiation to the lung and skin. Rats were treated with X-rays as follows: (1) 12.5 or 13 Gy whole thorax irradiation (WTI) (2) 30 Gy soft X-rays to 10% area of the skin only (3) 12.5 or 13 Gy WTI+30 Gy skin irradiation after 3 hours (4) 12.5 Gy WTI+skin irradiation and treated with captopril (160 mg/m2/day) started after 7 days. Our end points were survival (primary) based on IACUC euthanization criteria and secondary measurements of breathing intervals and skin injury. Lung collagen at 210 days was measured in rats surviving 13 Gy WTI. After 12.5 Gy WTI with or without skin irradiation, one rat (12.5 Gy WTI) was euthanized. Survival was less than 10% in rats receiving 13 Gy WTI, but was enhanced when combined with skin irradiation (p<0.0001). Collagen content increased at 210 days after 13 Gy WTI vs 13 Gy WTI+30 Gy skin irradiation (p<0.05). Captopril improved radiation-dermatitis after 12.5 Gy WTI+30 Gy skin irradiation (p=0.008). Radiation to the skin given 3 hours after WTI mitigated morbidity during pneumonitis in rats. Captopril enhanced the rate of healing of radiation-dermatitis after combined irradiations to the thorax and skin.
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影响因子：
38.9
作者：
Dancey, DR;Hayes, J;Stewart, TE
通讯作者：
Stewart, TE
影响因子：
3.4
作者：
Jourdan, M. M.;Lopez, A.;Lazarova, Z.
通讯作者：
Lazarova, Z.
影响因子：
2.2
作者：
LEDNEY, GD;STEWART, DA;SHEEHY, PA
通讯作者：
SHEEHY, PA
DOI：
10.1016/0273-1177(89)90438-9
发表时间：
1989-01-01
期刊：
Advances in space research : the official journal of the Committee on Space Research (COSPAR)
影响因子：
--
作者：
Messerschmidt, O
通讯作者：
Messerschmidt, O
DOI：
10.1097/01.ta.0000215434.24726.72
发表时间：
2007-01-01
影响因子：
--
作者：
Ran, Xin-Ze;Su, Yong-Ping;Cheng, Tian-Min
通讯作者：
Cheng, Tian-Min