Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases.
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases.
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DOI：
10.3389/fimmu.2020.610300
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发表时间：
2020
影响因子：
7.3
通讯作者：
Locatelli F
中科院分区：
文献类型：
--
作者：
Carsetti R;Zaffina S;Piano Mortari E;Terreri S;Corrente F;Capponi C;Palomba P;Mirabella M;Cascioli S;Palange P;Cuccaro I;Milito C;Zumla A;Maeurer M;Camisa V;Vinci MR;Santoro A;Cimini E;Marchioni L;Nicastri E;Palmieri F;Agrati C;Ippolito G;Porzio O;Concato C;Onetti Muda A;Raponi M;Quintarelli C;Quinti I;Locatelli F
SARS-CoV-2是一种新型冠状病毒，人类以前从未遇到过。SARS-CoV-2疾病的广泛临床表现表明，对SARS-CoV-2的个体免疫应答在确定首次感染后的临床病程中起着至关重要的作用。免疫学研究主要集中在中度至重度疾病患者，表明组织过度炎症和器官损伤。为了了解COVID-19中保护性免疫应答的基础，我们对64名具有一系列临床表现的成年人进行了先天性和获得性免疫的纵向随访、流式细胞术和血清学分析：28名健康的SARS-CoV-2阴性COVID-19接触者; 20名无症状的SARS-CoV-2感染者; 8例轻度COVID-19疾病患者和8例重度COVID-19疾病患者。我们的数据表明，高频率的NK细胞和特异性伊加，IgM的早期和短暂的增加，在较低程度上，IgG与无症状的SARS-CoV-2感染。相比之下，单核细胞扩增和伊加和IgG的高和持续水平，在感染过程中产生相对较晚，表征严重的疾病。在轻度COVID-19中检测到单核细胞的适度增加和抗体的不同动力学。先天性NK细胞的重要性以及无症状个体和轻度疾病患者的短暂抗体应答表明，只有重度COVID-19可能导致适应性免疫应答建立的保护性记忆。
SARS-CoV-2 is a novel coronavirus, not encountered before by humans. The wide spectrum of clinical expression of SARS-CoV-2 illness suggests that individual immune responses to SARS-CoV-2 play a crucial role in determining the clinical course after first infection. Immunological studies have focused on patients with moderate to severe disease, demonstrating excessive inflammation in tissues and organ damage. In order to understand the basis of the protective immune response in COVID-19, we performed a longitudinal follow-up, flow-cytometric and serological analysis of innate and adaptive immunity in 64 adults with a spectrum of clinical presentations: 28 healthy SARS-CoV-2-negative contacts of COVID-19 cases; 20 asymptomatic SARS-CoV-2-infected cases; eight patients with Mild COVID-19 disease and eight cases of Severe COVID-19 disease. Our data show that high frequency of NK cells and early and transient increase of specific IgA, IgM and, to a lower extent, IgG are associated with asymptomatic SARS-CoV-2 infection. By contrast, monocyte expansion and high and persistent levels of IgA and IgG, produced relatively late in the course of the infection, characterize severe disease. Modest increase of monocytes and different kinetics of antibodies are detected in mild COVID-19. The importance of innate NK cells and the short-lived antibody response of asymptomatic individuals and patients with mild disease suggest that only severe COVID-19 may result in protective memory established by the adaptive immune response.
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影响因子：
11.8
作者：
Bordoni, Veronica;Sacchi, Alessandra;Agrati, Chiara
通讯作者：
Agrati, Chiara
影响因子：
3.2
作者：
Baker, Michelle L.;Tachedjian, Mary;Wang, Lin-Fa
通讯作者：
Wang, Lin-Fa
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B
影响因子：
7.3
作者：
Diao, Bo;Wang, Chenhui;Chen, Yongwen
通讯作者：
Chen, Yongwen
影响因子：
7.3
作者：
Abel AM;Yang C;Thakar MS;Malarkannan S
通讯作者：
Malarkannan S