Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa-Exploratory Study.
Fractalkine, sICAM-1 and Kynurenine Pathway in Restrictive Anorexia Nervosa-Exploratory Study.
复制标题
限制性神经性厌食症中Fractalkine、sICAM-1和犬尿氨酸通路的探索性研究
DOI：
10.3390/nu13020339
复制
发表时间：
2021-01-24
期刊：
影响因子：
5.9
通讯作者：
Urbańska EM
中科院分区：
文献类型：
--
作者：
Dudzińska E;Szymona K;Kloc R;Kocki T;Gil-Kulik P;Bogucki J;Kocki J;Paduch R;Urbańska EM
犬尿氨酸途径和免疫调节分子fractalkine和可溶性细胞间粘附分子-1（sICAM-1）在神经性厌食症（AN）中的联系尚不清楚。研究了20例限制性AN女性患者（大部分无药物，均在疾病首次发作期间）和24例对照组中Fractalkine、sICAM-1、色氨酸（TRP）、犬尿氨酸（KYN）、神经保护性犬尿烯酸（KYNA）、神经毒性3-OH-犬尿氨酸（3-OH-KYN）和犬尿氨酸氨基转移酶（KAT 1 -3）的mRNA表达。在AN中，血清fractalkine而不是sICAM-1、KYNA、KYN、TRP或3-OH-KYN更高; TRP/KYN、KYN/KYNA、KYN/3-OH-KYN和KYNA/3-OH-KYN的比率不变。AN患者中编码KAT 3的基因的表达较高，但编码KAT 1和KAT 2的基因的表达（在血液单核细胞中测量）则不高。在AN中，Fractalkine与TRP呈正相关，而sICAM-1与3-OH-KYN呈负相关，与KYN/3-OH-KYN比值呈正相关。此外，TRP和Fractalkine与AN的体重指数（BMI）呈负相关。KAT 1、KAT 2和KAT 3的表达与Fractalkine、sICAM-1和BMI均无相关性。Fractalkine的增加可能是限制型AN的独立相关因素。过度的体力活动可能是在入选患者中观察到的KAT 3表达增加的基础。此外，对更大队列患者的纵向研究应旨在阐明Fractalkine和KAT 3对AN发病机制的贡献。
The link between the kynurenine pathway and immunomodulatory molecules—fractalkine and soluble intercellular adhesion molecule-1 (sICAM-1)—in anorexia nervosa (AN) remains unknown. Fractalkine, sICAM-1, tryptophan (TRP), kynurenine (KYN), neuroprotective kynurenic acid (KYNA), neurotoxic 3-OH-kynurenine (3-OH-KYN), and the expression of mRNA for kynurenine aminotransferases (KAT1-3) were studied in 20 female patients with restrictive AN (mostly drug-free, all during first episode of the disease) and in 24 controls. In AN, serum fractalkine, but not sICAM-1, KYNA, KYN, TRP or 3-OH-KYN, was higher; ratios TRP/KYN, KYN/KYNA, KYN/3-OH-KYN and KYNA/3-OH-KYN were unaltered. The expression of the gene encoding KAT3, but not of genes encoding KAT1 and KAT2 (measured in blood mononuclear cells), was higher in patients with AN. In AN, fractalkine positively correlated with TRP, while sICAM-1 was negatively associated with 3-OH-KYN and positively linked with the ratio KYN/3-OH-KYN. Furthermore, TRP and fractalkine were negatively associated with the body mass index (BMI) in AN. Expression of KAT1, KAT2 and KAT3 did not correlate with fractalkine, sICAM-1 or BMI, either in AN or control. Increased fractalkine may be an independent factor associated with the restrictive type of AN. Excessive physical activity probably underlies increased expression of KAT3 observed among enrolled patients. Further, longitudinal studies on a larger cohort of patients should be aimed to clarify the contribution of fractalkine and KAT3 to the pathogenesis of AN.
登录
查看更多内容
影响因子：
5.9
作者：
Dalton, Bethan;Campbell, Iain C.;Himmerich, Hubertus
通讯作者：
Himmerich, Hubertus
影响因子：
4.2
作者：
Dudzinska, Ewa;Szymona, Kinga;Urbanska, Ewa M.
通讯作者：
Urbanska, Ewa M.
影响因子：
4.7
作者：
Beggiato, Sarah;Tanganelli, Sergio;Ferraro, Luca
通讯作者：
Ferraro, Luca
影响因子：
15.1
作者：
Nilsson, Ida A. K.;Millischer, Vincent;Landen, Mikael
通讯作者：
Landen, Mikael
影响因子：
3.7
作者：
Gauthier, Claire;Hassler, Christine;Godart, Nathalie
通讯作者：
Godart, Nathalie