Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome.
Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome.
复制标题
DOI：
10.3390/antiox12050982
复制
发表时间：
2023-04-22
期刊：
影响因子：
7
通讯作者：
Rosenberg, Daniel W.
中科院分区：
文献类型：
--
作者：
Fan, Nuoxi;Fusco, Jennifer L.;Rosenberg, Daniel W.
核桃被称赞为“超级食品”，其中包含一系列显着的天然成分，这些成分可能具有额外的和/或协同特性，这些特性有助于降低癌症的风险。 ALA），生育酚，抗氧化剂多酚（包括ellagitannins）和益生元，包括纤维（2 g/oz）。以积极的方式促进肠道微生物组，具有益生元潜能，促进有益细菌的生长。对微生物组的作用，核桃的许多有益特性与一系列抗炎特性有关，包括对免疫系统的强大影响核桃的大多数一致性是ellagitannins，摄入后的原发性花梗，在低pH值下水解以释放Ellagitic Acid（EA），ellagitic Acid（EA）是一种非氟氟苯酚，随后由Microbiota对生物活性尿素（Hydroxydibenzo [hydroxydibenzo [hydroxydibenzo [ ，d] pyran-6-hone）。包括该螺母作为降低整体疾病风险的健康饮食的一部分，包括大肠癌。好处。
Walnuts have been lauded as a ‘superfood’, containing a remarkable array of natural constituents that may have additive and/or synergistic properties that contribute to reduced cancer risk. Walnuts are a rich source of polyunsaturated fatty acids (PUFAs: alpha-linolenic acid, ALA), tocopherols, antioxidant polyphenols (including ellagitannins), and prebiotics, including fiber (2 g/oz). There is a growing body of evidence that walnuts may contribute in a positive way to the gut microbiome, having a prebiotic potential that promotes the growth of beneficial bacteria. Studies supporting this microbiome-modifying potential include both preclinical cancer models as well as several promising human clinical trials. Mediated both directly and indirectly via its actions on the microbiome, many of the beneficial properties of walnuts are related to a range of anti-inflammatory properties, including powerful effects on the immune system. Among the most potent constituents of walnuts are the ellagitannins, primarily pedunculagin. After ingestion, the ellagitannins are hydrolyzed at low pH to release ellagic acid (EA), a non-flavonoid polyphenolic that is subsequently metabolized by the microbiota to the bioactive urolithins (hydroxydibenzo[b,d]pyran-6-ones). Several urolithins, including urolithin A, reportedly have potent anti-inflammatory properties. These properties of walnuts provide the rationale for including this tree nut as part of a healthy diet for reducing overall disease risk, including colorectal cancer. This review considers the latest information regarding the potential anti-cancer and antioxidant properties of walnuts and how they may be incorporated into the diet to provide additional health benefits.
登录
查看更多内容
影响因子：
3.7
作者：
Arab HH;Salama SA;Omar HA;Arafa el-SA;Maghrabi IA
通讯作者：
Maghrabi IA
多酚及其在生物医学研究中的抗癌特性的功能：叙事评论。
影响因子：
0.9
作者：
Bhosale PB;Ha SE;Vetrivel P;Kim HH;Kim SM;Kim GS
通讯作者：
Kim GS
影响因子：
5.9
作者：
Benninghoff, Abby D.;Hintze, Korry J.;Ward, Robert E.
通讯作者：
Ward, Robert E.
生物样本长链 N-3 PUFA 与结直肠癌风险：对 60,627 名个体数据的荟萃分析
影响因子：
3.7
作者：
Yang B;Wang FL;Ren XL;Li D
通讯作者：
Li D
影响因子：
2.9
作者：
Koller KR;Wilson A;Normolle DP;Nicholson JK;Li JV;Kinross J;Lee FR;Flanagan CA;Merculieff ZT;Iyer P;Lammers DL;Thomas TK;O'Keefe SJD
通讯作者：
O'Keefe SJD