Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals.
Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals.
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生物样本长链 N-3 PUFA 与结直肠癌风险：对 60,627 名个体数据的荟萃分析
DOI：
10.1371/journal.pone.0110574
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Yang B;Wang FL;Ren XL;Li D
几项前瞻性队列和病例对照研究报告了C20和C22长链（LC）N-3多不饱和脂肪酸（PUFA）的生物相结合之间的关联不一致。
截至2014年2月，搜索了符合条件的研究（RRS），或者使用最高剂量分类的分类组合，使用了Cochrane图书馆和EMBASE数据库。和本研究中包括三个前瞻性队列研究和8个病例对照研究，将非cas酶分析为6627名参与者（1,499例CRC病例，59,128例非cases）均为较高的Biospecimen LC N-3 PUFA（CRC较低的危险）。 I2 = 10.00％）和预期队列研究（汇总RR：0.70; 95％CI：0.55，0.88; i2 = 0.00％）分别发现了BiospeCimen C20：5N-3（非线性性= 0.02）的剂量响应关联。 N-3（SMD：0.27; 95％： 0.13，0.41），C22：6N-3（SMD：0.23; 95％：0.11，0.34）和总LC N-3 PUFA（SMD：0.22; 95％CI：0.07，0.37）与CRC相比。
目前的证据表明，LC N-3 PUFA的人体组织组成可能是CRC风险的独立预测因素，尤其是C20：5N-3和C22：6N-3。
Background Several prospective cohort and case-control studies reported the inconsistent association between biospecimen composition of C20 and C22 long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) and colorectal cancer (CRC) risk. The aim of the present study was to investigate the association of biospecimen LC n-3 PUFA with CRC risk based on prospective cohort and case-control studies. Methods and Results Cochrane Library, PubMed, and EMBASE database were searched up to February 2014 for eligible studies. Risk ratios (RRs) or odds ratios (ORs) from prospective and case-control studies were combined using a random-effects model in the highest vs. lowest categorical analysis. Nonlinear dose-response relationships were assessed using restricted cubic spline regression models. Difference in tissue composition of LC n-3 PUFA between cases and noncases was analyzed as standardized mean difference (SMD). Three prospective cohort studies and 8 case-control studies were included in the present study, comprising 60,627 participants (1,499 CRC cases and 59,128 noncases). Higher biospecimen LC n-3 PUFA was significantly associated with a lower risk of CRC in case-control (pooled OR: 0.76; 95% CI: 0.59, 0.97; I2 = 10.00%) and prospective cohort studies (pooled RR: 0.70; 95% CI: 0.55, 0.88; I2 = 0.00%), respectively. A significant dose-response association was found of biospecimen C20:5n-3 (P for nonlinearity = 0.02) and C22:6n-3 (P for trend = 0.01) with CRC risk, respectively. Subjects without CRC have significantly higher biospecimen compositions of C20:5n-3 (SMD: 0.27; 95%: 0.13, 0.41), C22:6n-3 (SMD: 0.23; 95%: 0.11, 0.34) and total LC n-3 PUFA (SMD: 0.22; 95% CI: 0.07, 0.37) compared with those with CRC. Conclusions The present evidence suggests human tissue compositions of LC n-3 PUFA may be an independent predictive factor for CRC risk, especially C20:5n-3 and C22:6n-3. This needs to be confirmed with more large-scale prospective cohort studies.
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