Altered default network resting state functional connectivity in patients with a first episode of psychosis.
Altered default network resting state functional connectivity in patients with a first episode of psychosis.
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DOI：
10.1016/j.schres.2012.05.005
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发表时间：
2012-08
影响因子：
4.5
通讯作者：
Castellanos, F. Xavier
中科院分区：
文献类型：
--
作者：
Alonso-Solis, Anna;Corripio, Iluminada;de Castro-Manglano, Pilar;Duran-Sindreu, Santiago;Garcia-Garcia, Manuel;Proal, Erika;Nunez-Marin, Fidel;Soutullo, Cesar;Alvarez, Enric;Gomez-Anson, Beatriz;Kelly, Clare;Castellanos, F. Xavier
关键词：
默认网络（DN）异常已被确定在慢性精神分裂症患者使用“静息态”功能磁共振成像（R-fMRI）。在这里，我们研究了DN的患者经历他们的第一次精神病发作（FEP）的完整性与性别和年龄匹配的健康对照。我们收集了19名FEP患者（平均年龄24.9±4.8岁，14名男性）和19名健康对照者（26.1±4.8岁，14名男性）在3特斯拉下的R-fMRI数据。在标准预处理后，我们检查了两个DN子系统和两个DN集线器的功能连接（FC）（P<0.0045，校正）。FEP患者表现出异常的FC，似乎主要限于背内侧前额叶皮层（dMPFC）DN子系统。相对于对照组，FEP患者表现出较弱的阳性FC之间的dMPFC和后扣带回皮质（PCC）和楔前叶，横向延伸通过顶叶后角回。FEP患者双侧颞叶外侧皮质和距内侧皮质之间的负FC较弱。与对照组相比，FEP患者的PCC和颞顶交界处也表现出较弱的负FC，右侧梭状回延伸到舌回和枕叶外侧皮质。而FEP患者颞极与内侧运动皮质、楔前叶前部和扣带回后部之间的负FC较强。FEP患者dMPFC DN子系统的异常表明，即使在精神病的早期阶段，FC模式也会改变。
Default network (DN) abnormalities have been identified in patients with chronic schizophrenia using “resting state” functional magnetic resonance imaging (R-fMRI). Here, we examined the integrity of the DN in patients experiencing their first episode of psychosis (FEP) compared with sex- and age-matched healthy controls. We collected R-fMRI data from 19 FEP patients (mean age 24.9±4.8 yrs, 14 males) and 19 healthy controls (26.1±4.8 yrs, 14 males) at 3 Tesla. Following standard preprocessing, we examined the functional connectivity (FC) of two DN subsystems and the two DN hubs (P<0.0045, corrected). Patients with FEP exhibited abnormal FC that appeared largely restricted to the dorsomedial prefrontal cortex (dMPFC) DN subsystem. Relative to controls, FEP patients exhibited weaker positive FC between dMPFC and posterior cingulate cortex (PCC) and precuneus, extending laterally through the parietal lobe to the posterior angular gyrus. Patients with FEP exhibited weaker negative FC between the lateral temporal cortex and the intracalcarine cortex, bilaterally. The PCC and temporo-parietal junction also exhibited weaker negative FC with the right fusiform gyrus extending to the lingual gyrus and lateral occipital cortex, in FEP patients, compared to controls. By contrast, patients with FEP showed stronger negative FC between the temporal pole and medial motor cortex, anterior precuneus and posterior mid-cingulate cortex. Abnormalities in the dMPFC DN subsystem in patients with a FEP suggest that FC patterns are altered even in the early stages of psychosis.
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发表时间：
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影响因子：
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