Amygdala involvement in human avoidance, escape and approach behavior.
Amygdala involvement in human avoidance, escape and approach behavior.
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DOI：
10.1016/j.neuroimage.2010.06.058
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发表时间：
2010-11-01
期刊：
影响因子：
5.7
通讯作者：
Cataldo, Michael F.
中科院分区：
文献类型：
--
作者：
Schlund, Michael W.;Cataldo, Michael F.
许多形式的精神病理学和药物滥用问题的特征是慢性仪式化形式的回避和逃避行为，旨在控制或修改外部或内部（即思想，情绪，身体感觉）的威胁。在这项功能性磁共振成像研究中，我们检查了杏仁核对威胁性线索的反应，当回避反应持续阻止接触即将到来的厌恶事件（金钱损失）时。此外，我们研究了逃避反应，终止立即升级的金钱损失和方法反应，产生了未来的金钱收益。结果表明，提示回避，逃避和接近行为招募了类似的额-纹状体-顶叶网络。在杏仁核内，双边激活被观察到的威胁回避和逃避线索，即使金钱损失一直避免，以及奖励线索。杏仁核内的主题反应的幅度是相对相似的回避，逃避和方法cues，但相当大的主题之间的差异被发现，提高杏仁核反应的回避和逃避cues内观察到的一个子集的主题表明，威胁相关的反应，可以保持即使厌恶的事件是一贯避免，这可能会解释在各种临床疾病的回避应对的持久性。进一步评估杏仁核反应性和回避逃避行为之间的关系可能有助于识别神经精神疾病或有风险的个体。
Many forms of psychopathology and substance abuse problems are characterized by chronic ritualized forms of avoidance and escape behavior that are designed to control or modify external or internal (i.e, thoughts, emotions, bodily sensations) threats. In this functional magnetic resonance imaging investigation, we examined amygdala reactivity to threatening cues when avoidance responding consistently prevented contact with an upcoming aversive event (money loss). In addition, we examined escape responding that terminated immediate escalating money loss and approach responding that produced a future money gain. Results showed cues prompting avoidance, escape and approach behavior recruited a similar fronto-striatal-parietal network. Within the amygdala, bilateral activation was observed to threatening avoidance and escape cues, even though money loss was consistently avoided, as well as to the reward cue. The magnitude of amygdala responses within-subjects was relatively similar to avoidance, escape and approach cues, but considerable between-subject differences were found. The heightened amygdala response to avoidance and escape cues observed within a subset of subjects suggests threat related responses can be maintained even when aversive events are consistently avoided, which may account for the persistence of avoidance-coping in various clinical disorders. Further assessment of the relation between amygdala reactivity and avoidance-escape behavior may prove useful in identifying individuals with or at risk for neuropsychiatric disorders.
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影响因子：
7.6
作者：
CIOFFI, D;HOLLOWAY, J
通讯作者：
HOLLOWAY, J
影响因子：
3.3
作者：
Andrzejewski, ME;Spencer, RC;Kelley, AE
通讯作者：
Kelley, AE
DOI：
10.1007/bf03392173
发表时间：
2009-03-01
期刊：
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影响因子：
--
作者：
Dymond, Simon;Roche, Bryan
通讯作者：
Roche, Bryan
影响因子：
4.1
作者：
Campbell-Sills, Laura;Barlow, David H.;Hofmann, Stefan G.
通讯作者：
Hofmann, Stefan G.
影响因子：
4.1
作者：
Feldner, MT;Zvolensky, MJ;Leen-Feldner, EW
通讯作者：
Leen-Feldner, EW