Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.
Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.
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DOI：
10.1016/j.pscychresns.2013.06.013
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发表时间：
2013-12-30
影响因子：
11.3
通讯作者：
Phillips M
中科院分区：
文献类型：
--
作者：
Diler RS;de Almeida JR;Ladouceur C;Birmaher B;Axelson D;Phillips M
Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1±1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents.
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影响因子：
5.7
作者：
Foland-Ross LC;Bookheimer SY;Lieberman MD;Sugar CA;Townsend JD;Fischer J;Torrisi S;Penfold C;Madsen SK;Thompson PM;Altshuler LL
通讯作者：
Altshuler LL
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1176/appi.ajp.2009.09010043
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brotman MA;Rich BA;Guyer AE;Lunsford JR;Horsey SE;Reising MM;Thomas LA;Fromm SJ;Towbin K;Pine DS;Leibenluft E
通讯作者：
Leibenluft E
影响因子：
10.6
作者：
Almeida, Jorge R. C.;Versace, Amelia;Hassel, Stefanie;Kupfer, David J.;Phillips, Mary L.
通讯作者：
Phillips, Mary L.
影响因子：
10.6
作者：
Cardoso de Almeida, Jorge Renner;Versace, Amelia;Mechelli, Andrea;Hassel, Stefanie;Quevedo, Karina;Kupfer, David Jerome;Phillips, Mary Louise
通讯作者：
Phillips, Mary Louise