Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells.
Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells.
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DOI：
10.1007/s00266-007-9019-4
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发表时间：
2008-01
影响因子：
2.4
通讯作者：
Harii K
中科院分区：
文献类型：
--
作者：
Yoshimura K;Sato K;Aoi N;Kurita M;Hirohi T;Harii K
脂肪注射是一种很有前途的治疗方法，但也存在一些问题，如不可预测性和移植物部分坏死导致的存活率低。为了克服脂肪注射的问题，作者开发了一种称为细胞辅助脂肪转移（CAL）的新策略。在CAL中，自体脂肪源性干细胞（基质）细胞（ASC）与脂肪注射联合使用。将含有ASC的基质血管部分（SVF）从一半的抽吸脂肪新鲜分离并与另一半重组。该过程将相对ASC贫乏的抽吸脂肪转化为富含ASC的脂肪。本报告介绍了40例接受CAL美容隆乳的患者的结果。平均注射270 ml脂肪后，最终乳房体积增大100 - 200 ml。注射脂肪的术后萎缩是最小的，并且在2个月后没有实质性变化。在4例患者中检测到囊肿形成或微钙化。几乎所有的患者都对柔软自然的隆乳感到满意。初步结果表明，CAL用于软组织填充是有效和安全的，并且上级优于常规脂肪注射。有必要进行进一步的研究以进一步评估该技术的有效性。
Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis. To overcome the problems with lipoinjection, the authors developed a novel strategy known as cell-assisted lipotransfer (CAL). In CAL, autologous adipose-derived stem (stromal) cells (ASCs) are used in combination with lipoinjection. A stromal vascular fraction (SVF) containing ASCs is freshly isolated from half of the aspirated fat and recombined with the other half. This process converts relatively ASC-poor aspirated fat to ASC-rich fat. This report presents the findings for 40 patients who underwent CAL for cosmetic breast augmentation. Final breast volume showed augmentation by 100 to 200 ml after a mean fat amount of 270 ml was injected. Postoperative atrophy of injected fat was minimal and did not change substantially after 2 months. Cyst formation or microcalcification was detected in four patients. Almost all the patients were satisfied with the soft and natural-appearing augmentation. The preliminary results suggest that CAL is effective and safe for soft tissue augmentation and superior to conventional lipoinjection. Additional study is necessary to evaluate the efficacy of this technique further.
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影响因子：
3.3
作者：
Zuk, PA;Zhu, M;Hedrick, MH
通讯作者：
Hedrick, MH
影响因子：
37.8
作者：
Rehman, J;Traktuev, D;March, KL
通讯作者：
March, KL
影响因子：
37.8
作者：
Miranville, A;Heeschen, C;Bouloumié, A
通讯作者：
Bouloumié, A
影响因子：
3.6
作者：
Ullmann, Y;Hyams, M;Lindenbaum, ES
通讯作者：
Lindenbaum, ES
DOI：
10.1152/ajpendo.00093.2003
发表时间：
2004-04-01
影响因子：
5.1
作者：
Strawford, A;Antelo, F;Hellerstein, MK
通讯作者：
Hellerstein, MK