Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection.
Cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection.
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DOI：
10.1007/s10096-010-1041-9
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发表时间：
2011-01
影响因子：
4.5
通讯作者：
Kawashima, H.
中科院分区：
文献类型：
--
作者：
Takano, T.;Tajiri, H.;Kashiwagi, Y.;Kimura, S.;Kawashima, H.
我们报告了2009年甲型H1N1流感病毒感染儿童的全身细胞因子和趋化因子反应。肺炎患者血清IFN-γ和IL-5水平显著高于非肺炎患者。在肺炎患者中，IL-6、IL-8、IL-10、IL-13和MCP-1也存在这种趋势。在肺炎患者中，MCP-1水平在肺炎合并重度呼吸衰竭组中显著高于轻度肺炎组。
We report the systemic cytokine and chemokine response in children with the 2009 pandemic influenza A (H1N1) virus infection. In patients with pneumonia, the serum levels of IFN-γ and IL-5 were significantly higher than those in patients without pneumonia. This tendency was also present for IL-6, IL-8, IL-10, IL-13, and MCP-1 in patients with pneumonia. Among patients with pneumonia, the levels of MCP-1 were significantly higher in the group of patients with pneumonia with severe respiratory failure than patients with mild pneumonia.
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