Relationship between ADHD and anxiety in boys: results from a family study.
Relationship between ADHD and anxiety in boys: results from a family study.
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男孩多动症和焦虑之间的关系：家庭研究的结果。
DOI：
10.1097/00004583-199608000-00009
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Last,CG
中科院分区：
文献类型：
--
作者：
Perrin,S;Last,CG
最近的研究发现，与正常对照组的成年亲属相比，ADHD儿童的成年亲属患焦虑症和注意力缺陷多动障碍（ADHD）的风险增加。这些发现可能解释了ADHD儿童中高比例的共病焦虑，并且它们表明这两种疾病之间存在关系。然而，需要更多的研究来解决这种关系，包括焦虑症和正常对照组。（n = 1，266）临床转诊的ADHD男孩（n = 49），临床转诊的焦虑症男孩（n = 46），对照组37例，采用结构化访谈法进行评估，并根据DSM-III-R诊断标准进行诊断。比较三组先证者亲属ADHD和焦虑障碍的终生患病率，发现ADHD先证者的女性亲属焦虑障碍患病率显著高于NPI对照组的女性亲属。然而，焦虑先证者和NPI对照者的亲属在ADHD方面没有差异。此外，没有证据的共隔离焦虑症与ADHD被发现在两个病人groups.CONCLUSIONSADHD和焦虑的先证者的亲属可能有共同的危险因素，但似乎是独立的家庭传播。ADHD先证者的女性亲属的高焦虑率与焦虑先证者的亲属的高焦虑率相当，值得进一步调查。
OBJECTIVERecent studies have found an increased risk for both anxiety disorder and attention-deficit hyperactivity disorder (ADHD) in the adult relatives of children with ADHD in comparison with adult relatives of normal controls. Such findings may account for the high rates of comorbid anxiety found in children with ADHD, and they suggest a relationship between the two disorders. However, additional studies are needed to address this relationship that include both anxiety disorder and normal control groups.METHODThe first- (n = 239) and second-degree relatives (n = 1,266) of clinically referred boys with ADHD (n = 49), clinically referred boys with anxiety disorder (n = 46), and controls who have never been psychiatrically ill (NPI controls) (n = 37) were assessed with structured interview and diagnosed according to DSM-III-R criteria. Lifetime rates of ADHD and anxiety disorder were then compared for relatives in the three proband groups.RESULTSFemale relatives of ADHD probands had significantly higher rates of anxiety disorder than female relatives of NPI controls. However, relatives of anxious probands and NPI controls did not differ for ADHD. Furthermore, no evidence of cosegregation of anxiety disorder with ADHD was found in the relatives of probands in the two patient groups.CONCLUSIONSADHD and anxiety may share common risk factors but appear to be independently transmitted in families. The high rate of anxiety in female relatives of ADHD probands was comparable with that found in relatives of anxious probands and warrants further investigation.
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影响因子：
--
作者：
Chambers,WJ;Puig-Antich,J;Hirsch,M;Paez,P;Ambrosini,PJ;Tabrizi,MA;Davies,M
通讯作者：
Davies,M
患有注意缺陷多动障碍的成人的精神共病、认知和心理社会功能的模式。
DOI：
10.1176/ajp.150.12.1792
发表时间：
1993
期刊：
The American journal of psychiatry
影响因子：
--
作者：
J. Biederman;S. Faraone;T. Spencer;T. Wilens;Dennis K. Norman;K. A. Lapey;E. Mick;B. K. Lehman;A. Doyle
通讯作者：
A. Doyle
影响因子：
--
作者：
M. Weissman;K. Merikangas;K. John;P. Wickramaratne;B. Prusoff;K. Kidd
通讯作者：
M. Weissman;K. Merikangas;K. John;P. Wickramaratne;B. Prusoff;K. Kidd
患有强迫症的儿童和青少年的一级亲属的精神疾病。
影响因子：
13.3
作者：
M. Lenane;S. Swedo;H. Leonard;D. Pauls;W. Sceery;J. Rapoport
通讯作者：
J. Rapoport
影响因子：
--
作者：
C. G. Last;M. Hersen;A. Kazdin;H. Orvaschel;S. Perrin
通讯作者：
C. G. Last;M. Hersen;A. Kazdin;H. Orvaschel;S. Perrin