Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases.
Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases.
复制标题
操纵抗原呈递用于自身免疫性疾病的抗原特异性免疫治疗。
DOI：
10.1016/j.coi.2021.03.019
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发表时间：
2021-06
影响因子：
7
通讯作者：
Wraith DC
中科院分区：
文献类型：
--
作者：
Streeter HB;Wraith DC
特异性免疫疗法是治疗自身免疫疾病的“圣杯”。抗原通过直接或间接递送机制递送。肝脏APC和稳态DC介导不同形式的免疫调节。TR1细胞诱导涉及耐受相关基因的表观遗传修饰。试验表明，抗原特异性免疫疗法可以控制自身免疫性疾病。目前对自身免疫性疾病的治疗方法没有解决其发生和发展的免疫病理基础，而且往往依赖于非特异性免疫抑制药物来控制症状。抗原特异性免疫疗法旨在有选择地在导致疾病的细胞之间诱导耐受，同时使适应性免疫系统的其余部分能够预防传染病和癌症。在这里，我们描述了如何设计新的抗原特异性免疫治疗方法来操纵抗原递呈和促进对特定自身抗原的耐受性。这项分析指出，以载体颗粒为靶点的肝脏抗原提呈细胞和稳定状态的树突状细胞是抗原特异性免疫治疗的主要靶点，这些细胞与抗原处理独立的T细胞表位直接结合。将抗原输送到这些细胞，为有效控制这一迅速扩大的疾病群带来了巨大的希望。
Specific immunotherapy is the ‘holy grail’ for treatment of autoimmunity. Antigens are delivered by either direct or indirect presentation mechanisms. Liver APC and steady state DC mediate distinct forms of immune regulation. Tr1 cell induction involves epigenetic modification of tolerance associated genes. Trials reveal that antigen-specific immunotherapy can control autoimmune diseases. Current treatments for autoimmune diseases do not address the immune pathology underlying their initiation and progression and too often rely on non-specific immunosuppressive drugs for control of symptoms. Antigen-specific immunotherapy aims to induce tolerance selectively among the cells causing the disease while leaving the rest of the adaptive immune system capable of protecting against infectious diseases and cancers. Here we describe how novel approaches for antigen-specific immunotherapy are designed to manipulate antigen presentation and promote tolerance to specific self-antigens. This analysis points to liver antigen presenting cells, targeted by carrier particles, and steady-state dendritic cells, to which antigen-processing independent T-cell epitopes (apitopes) bind directly, as the principal targets for antigen-specific immunotherapy. Delivery of antigens to these cells holds great promise for effective control of this rapidly expanding group of diseases.
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影响因子：
7.7
作者：
Hänninen, A;Braakhuis, A;Harrison, LC
通讯作者：
Harrison, LC
影响因子：
29.7
作者：
Hammer GE;Ma A
通讯作者：
Ma A
DOI：
10.1084/jem.193.1.1
发表时间：
2001-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Anderton SM;Radu CG;Lowrey PA;Ward ES;Wraith DC
通讯作者：
Wraith DC
影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
DOI：
10.1084/jem.194.6.769
发表时间：
2001-09-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hawiger D;Inaba K;Dorsett Y;Guo M;Mahnke K;Rivera M;Ravetch JV;Steinman RM;Nussenzweig MC
通讯作者：
Nussenzweig MC