Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring.
Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring.
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DOI：
10.1371/journal.pone.0005870
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发表时间：
2009-06-11
期刊：
影响因子：
3.7
通讯作者：
Coen CW
中科院分区：
文献类型：
--
作者：
Kirk SL;Samuelsson AM;Argenton M;Dhonye H;Kalamatianos T;Poston L;Taylor PD;Coen CW
Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed an obesogenic diet prior to and throughout pregnancy and lactation. We now report that offspring of obese (OffOb) rats display an amplified and prolonged neonatal leptin surge, which is accompanied by elevated leptin mRNA expression in their abdominal white adipose tissue. At postnatal Day 30, before the onset of hyperphagia in these animals, serum leptin is normal, but leptin-induced appetite suppression and phosphorylation of STAT3 in the arcuate nucleus (ARC) are attenuated; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus (PVH), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished. We hypothesise that prolonged release of abnormally high levels of leptin by neonatal OffOb rats leads to leptin resistance and permanently affects hypothalamic functions involving the ARC and PVH. Such effects may underlie the developmental programming of hyperphagia and obesity in these rats.
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影响因子：
16.2
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
通讯作者：
Elmquist, JK
影响因子：
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DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
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作者：
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通讯作者：
Amini, SB
影响因子：
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作者：
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通讯作者：
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