Effect of Attention Training on Attention Bias Variability and PTSD Symptoms: Randomized Controlled Trials in Israeli and U.S. Combat Veterans.
Effect of Attention Training on Attention Bias Variability and PTSD Symptoms: Randomized Controlled Trials in Israeli and U.S. Combat Veterans.
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DOI：
10.1176/appi.ajp.2015.14121578
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Bar-Haim Y
中科院分区：
文献类型：
--
作者：
Badura-Brack AS;Naim R;Ryan TJ;Levy O;Abend R;Khanna MM;McDermott TJ;Pine DS;Bar-Haim Y
创伤后应激障碍（PTSD）患者对威胁的注意力分配受到干扰，一些研究表明对威胁的过度关注，另一些研究表明威胁警惕和威胁回避之间的波动。作者测试了两种可供选择的计算机化方案的有效性，即注意力偏差修正和注意力控制训练，用于纠正威胁出勤模式和减少PTSD症状。两项随机对照试验比较了注意力偏差修正和注意力控制训练对PTSD的疗效：一项在以色列国防军退伍军人中进行，另一项在美国退伍军人中进行。两者都利用了点探测任务的变体，注意力偏差修正旨在将注意力从威胁转移开，注意力控制训练在威胁和中性刺激之间平衡注意力分配。在治疗前后测量PTSD症状、注意偏差和注意偏差变异性。两项研究均表明治疗后症状显著改善，有利于注意力控制训练。此外，两项研究都发现，注意力控制训练，而不是注意力偏差的修改，显着降低注意力偏差的变化。最后，对两个样本的综合分析表明，注意力偏差变异性的减少部分介导了PTSD症状的改善。注意力控制训练可以解决PTSD中注意力分配的异常波动，从而减少PTSD症状。需要进一步研究治疗效果及其潜在的神经认知机制。ClinicalTrials.gov注册标识符：NCT 01368302、NCT 01564667。
Attention allocation to threat is perturbed in patients with posttraumatic stress disorder (PTSD), with some studies indicating excess attention to threat and others indicating fluctuations between threat vigilance and threat avoidance. The authors tested the efficacy of two alternative computerized protocols, attention bias modification and attention controltraining, for rectifying threat attendance patterns and reducing PTSD symptoms. Two randomized controlled trials compared the efficacy of attention bias modification and attention control training for PTSD: one in Israel Defense Forces veteransand one in U.S. military veterans. Both utilized variants of the dot-probe task, with attention bias modification designed to shift attention away from threat and attention control training balancing attention allocation between threat and neutral stimuli. PTSD symptoms, attention bias, and attention bias variability were measured before and after treatment. Both studies indicated significant symptom improvement after treatment, favoring attention control training. Additionally, both studies found that attention control training, but not attention bias modification, significantly reduced attention bias variability. Finally, a combined analysis of the two samples suggested that reductions in attention bias variability partially mediated improvement in PTSD symptoms. Attention control training may address aberrant fluctuations in attention allocation in PTSD, thereby reducing PTSD symptoms. Further study of treatment efficacy and its underlying neurocognitive mechanisms is warranted. ClinicalTrials.gov registration identifiers: NCT01368302, NCT01564667.
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影响因子：
4.6
作者：
Constans, JI;McCloskey, MS;Mathews, A
通讯作者：
Mathews, A
注意偏置变异性和创伤后应激障碍的症状。
影响因子：
3.3
作者：
Iacoviello BM;Wu G;Abend R;Murrough JW;Feder A;Fruchter E;Levinstein Y;Wald I;Bailey CR;Pine DS;Neumeister A;Bar-Haim Y;Charney DS
通讯作者：
Charney DS
影响因子：
10.6
作者：
Hakamata, Yuko;Lissek, Shmuel;Bar-Haim, Yair;Britton, Jennifer C.;Fox, Nathan A.;Leibenluft, Ellen;Ernst, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH
影响因子：
3.7
作者：
Beard C;Sawyer AT;Hofmann SG
通讯作者：
Hofmann SG