The development of functional network organization in early childhood and early adolescence: A resting-state fNIRS study.
The development of functional network organization in early childhood and early adolescence: A resting-state fNIRS study.
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儿童早期和青春期早期功能网络组织的发展：静息态 fNIRS 研究
DOI：
10.1016/j.dcn.2018.03.003
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发表时间：
2018-04
影响因子：
4.7
通讯作者：
Niu H
中科院分区：
文献类型：
--
作者：
Cai L;Dong Q;Niu H
儿童早期（7-8岁）和青少年早期（11-12岁）是两个具有里程碑意义的发展阶段，包括神经认知的重大变化。然而，从功能性神经影像学研究中得到的关于人类大脑在特定发育时期的功能拓扑结构的信息非常有限。在本研究中，我们利用连续静息状态功能近红外光谱（rs-fNIRS）成像数据来研究从儿童早期和青少年早期到成年发育过程中网络组织的拓扑变化。研究结果表明，小世界性和模块性在发育过程中没有显著差异，这表明儿童早期大脑重要功能组织的发育成熟。有趣的是，幼儿的整体效率明显低于早期青少年和成年人，这表明分布式网络的整合在认知发展的各个发展阶段得到加强。此外，幼儿和青少年的局部效率显著低于成人，而两组之间没有差异。这一发现表明，从儿童早期到青少年早期，功能分离保持相对稳定，在这些发育时期的大脑没有最佳的网络结构。此外，我们还发现大脑不同区域的区域节点特性具有异质的发育模式，如额叶皮层节点特性呈线性增加，表明认知能力随着发育而增加。总的来说，我们的研究结果表明，在这两个关键的发育阶段，功能网络组织发生了显著的拓扑变化，并为阐明大脑功能网络在发育过程中的细微变化提供了新的见解。
Early childhood (7–8 years old) and early adolescence (11–12 years old) constitute two landmark developmental stages that comprise considerable changes in neural cognition. However, very limited information from functional neuroimaging studies exists on the functional topological configuration of the human brain during specific developmental periods. In the present study, we utilized continuous resting-state functional near-infrared spectroscopy (rs-fNIRS) imaging data to examine topological changes in network organization during development from early childhood and early adolescence to adulthood. Our results showed that the properties of small-worldness and modularity were not significantly different across development, demonstrating the developmental maturity of important functional brain organization in early childhood. Intriguingly, young children had a significantly lower global efficiency than early adolescents and adults, which revealed that the integration of the distributed networks strengthens across the developmental stages underlying cognitive development. Moreover, local efficiency of young children and adolescents was significantly lower than that of adults, while there was no difference between these two younger groups. This finding demonstrated that functional segregation remained relatively steady from early childhood to early adolescence, and the brain in these developmental periods possesses no optimal network configuration. Furthermore, we found heterogeneous developmental patterns in the regional nodal properties in various brain regions, such as linear increased nodal properties in the frontal cortex, indicating increasing cognitive capacity over development. Collectively, our results demonstrated that significant topological changes in functional network organization occurred during these two critical developmental stages, and provided a novel insight into elucidating subtle changes in brain functional networks across development.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
5.3
作者：
Baker, Simon T. E.;Lubman, Dan I.;Fornito, Alex
通讯作者：
Fornito, Alex
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y