Lesions of the Head Direction Cell System Increase Hippocampal Place Field Repetition.
Lesions of the Head Direction Cell System Increase Hippocampal Place Field Repetition.
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DOI：
10.1016/j.cub.2017.07.071
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发表时间：
2017-09-11
期刊：
影响因子：
--
通讯作者：
Dudchenko PA
中科院分区：
文献类型：
--
作者：
Harland B;Grieves RM;Bett D;Stentiford R;Wood ER;Dudchenko PA
系统神经科学的一个中心原则是哺乳动物的海马体提供了环境的认知图。这一观点得到了位置细胞的发现的支持，位置细胞是神经元，其放电被调整到动物环境中该大脑区域内的特定位置。然而，最近的研究表明，这些细胞在视觉上相同的迷宫隔室中重复它们的发射场。如果这些区室面向不同的方向，则不会观察到这种重复，这表明位置细胞使用方向输入来区分其他相似的局部环境。该输入的一个明显候选者是头部方向细胞系统。为了测试这一点，我们通过损害外侧乳头核来破坏头部方向细胞系统，然后当大鼠探索多个相连的隔室时记录位置细胞，这些隔室朝向相同或不同的方向。如前所述，我们发现对照动物中的位置细胞在平行排列的隔室中表现出重复的场，但在面向不同方向的隔室中则没有。相比之下，头部方向细胞系统受损的动物的位置细胞在两种情况下都表现出重复的场。因此，头部方向单元系统提供的方向信息对于通过视觉上相同的隔室的位置单元进行角度消歧显得至关重要。位置场在平行迷宫隔室中重复，但不是径向隔室 外侧乳头核病变增加径向隔室中的场重复 头部方向细胞可能驱动位置场 Harland 等人。结果表明，侧乳头核（头部方向回路中的重要节点）的病变增加了面向不同方向的迷宫隔间的位置场重复。这表明位置细胞和头部方向细胞协同工作以消除相似局部环境的歧义。
A central tenet of systems neuroscience is that the mammalian hippocampus provides a cognitive map of the environment. This view is supported by the finding of place cells, neurons whose firing is tuned to specific locations in an animal’s environment, within this brain region. Recent work, however, has shown that these cells repeat their firing fields across visually identical maze compartments. This repetition is not observed if these compartments face different directions, suggesting that place cells use a directional input to differentiate otherwise similar local environments. A clear candidate for this input is the head direction cell system. To test this, we disrupted the head direction cell system by lesioning the lateral mammillary nuclei and then recorded place cells as rats explored multiple, connected compartments, oriented in the same or in different directions. As shown previously, we found that place cells in control animals exhibited repeated fields in compartments arranged in parallel, but not in compartments facing different directions. In contrast, the place cells of animals with lesions of the head direction cell system exhibited repeating fields in both conditions. Thus, directional information provided by the head direction cell system appears essential for the angular disambiguation by place cells of visually identical compartments. Place fields repeat across parallel maze compartments, but not radial compartments Lateral mammillary nuclei lesions increase field repetition in radial compartments Head direction cells may drive place fields Harland et al. show that lesions of the lateral mammillary nuclei, essential nodes in the head direction circuit, increase place field repetition across maze compartments facing different directions. This suggests that place cells and head direction cells work together to allow disambiguation of similar local environments.
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