Individual Variability in Brain Activity: A Nuisance or an Opportunity?
Individual Variability in Brain Activity: A Nuisance or an Opportunity?
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DOI：
10.1007/s11682-008-9049-9
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发表时间：
2008-12-01
影响因子：
3.2
通讯作者：
Miller, Michael B.
中科院分区：
文献类型：
--
作者：
Van Horn, John Darrell;Grafton, Scott T.;Miller, Michael B.
功能成像研究受到基于群体水平推断的结果的严重影响。然而，群体平均结果可能掩盖了个体中存在的通常被认为是随机噪声的独特活动模式。MRI硬件发展的最新进展已导致血氧水平依赖（BOLD）测量的稳定性和再现性的显著改善。这些增强功能为更仔细地检查大脑活动的个体模式提供了独特的机会。通过在个体水平上考虑脑扫描可以实现三个目标：（1）在细粒度分析中绘制功能解剖图;（2）确定个体扫描相对于参考人群是否规范;（3）了解脑活动中受试者间差异的来源。在这篇综述中，我们详细介绍了这些目标，简要讨论了它们的历史，并提出了最近的趋势，在个体变异性的分析。最后，我们强调通过环太平洋地区调查人员之间的国际合作来了解个体差异的独特机遇和挑战。
Functional imaging research has been heavily influenced by results based on population-level inference. However, group average results may belie the unique patterns of activity present in the individual that ordinarily are considered random noise. Recent advances in the evolution of MRI hardware have led to significant improvements in the stability and reproducibility of blood oxygen level dependent (BOLD) measurements. These enhancements provide a unique opportunity for closer examination of individual patterns of brain activity. Three objectives can be accomplished by considering brain scans at the individual level; (1) Mapping functional anatomy at a fine grained analysis; (2) Determining if an individual scan is normative with respect to a reference population; and (3) Understanding the sources of intersubject variability in brain activity. In this review, we detail these objectives, briefly discuss their histories and present recent trends in the analyses of individual variability. Finally, we emphasize the unique opportunities and challenges for understanding individual differences through international collaboration among Pacific Rim investigators.
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