Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces.
Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces.
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生物启动的脚手架设计，用于再生肌肉骨骼组织界面。
DOI：
10.1007/s40883-019-00132-3
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发表时间：
2020-12
影响因子：
2.6
通讯作者：
Laurencin CT
中科院分区：
文献类型：
--
作者：
Barajaa MA;Nair LS;Laurencin CT
肌肉骨骼系统以非常先进的同步水平工作，身体的所有生理运动都是通过骨骼与所有其他肌肉骨骼软组织（例如韧带、肌腱、肌肉和软骨）通过组织-组织界面组织良好的动作系统地执行的。界面在结构和成分上都很复杂，由细胞外基质成分、细胞表型以及生化成分的梯度组成，并且对于介导身体运动期间不同骨科组织之间的负荷转移非常重要。当界面发生损伤时，必须重新建立以恢复其功能和稳定性。由于界面中发现的结构和成分复杂性，预计它们预示着相关再生工程方法和支架设计的复杂性随之增加，以实现成功的界面再生和工程骨科组织的无缝整合。在这里，我们讨论用于再生骨科组织界面的各种仿生支架设计。首先，我们从讨论界面处的结构-功能关系开始。然后，我们讨论目前对界面再生机制的理解，然后讨论目前临床上可用于治疗界面损伤的治疗方法。最后，我们全面讨论用于再生骨科组织界面的最先进的支架设计。骨科组织通过界面相互连接，界面在不同组织之间传递机械载荷方面发挥着重要作用。受伤后，必须重新建立界面以恢复关节功能和稳定性。了解控制界面开发的机制可能会导致成功的界面重建和支架设计。本文讨论了界面结构与功能关系的最新知识、界面再生的机制、目前临床上治疗界面损伤的治疗方法，以及再生复杂骨科组织界面的仿生支架设计和工程策略。
The musculoskeletal system works at a very advanced level of synchrony, where all the physiological movements of the body are systematically performed through well-organized actions of bone in conjunction with all the other musculoskeletal soft tissues, such as ligaments, tendons, muscles, and cartilage through tissue-tissue interfaces. Interfaces are structurally and compositionally complex, consisting of gradients of extracellular matrix components, cell phenotypes as well as biochemical compositions and are important in mediating load transfer between the distinct orthopedic tissues during body movement. When an injury occurs at interface, it must be re-established to restore its function and stability. Due to the structural and compositional complexity found in interfaces, it is anticipated that they presuppose a concomitant increase in the complexity of the associated regenerative engineering approaches and scaffold designs to achieve successful interface regeneration and seamless integration of the engineered orthopedic tissues. Herein, we discuss the various bioinspired scaffold designs utilized to regenerate orthopedic tissue interfaces. First, we start with discussing the structure-function relationship at the interface. We then discuss the current understanding of the mechanism underlying interface regeneration, followed by discussing the current treatment available in the clinic to treat interface injuries. Lastly, we comprehensively discuss the state-of-the-art scaffold designs utilized to regenerate orthopedic tissue interfaces. Orthopedic tissues are connected to one another through interfaces that play an important role in transitioning mechanical loads between the disparate tissues. After an injury, interfaces must be re-established in order to restore joint function and stability. Understanding the mechanism governing the development of interfaces may lead to successful interface re-establishment and scaffold designs. This article discusses the current knowledge of the structure-function relationship at the interface, the mechanism underlying interface regeneration, the current treatment available in the clinic to treat interface injuries, as well as bioinspired scaffold designs and engineering strategies to regenerate the complex orthopedic tissue interfaces.
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影响因子：
10
作者：
Caliari, Steven R.;Weisgerber, Daniel W.;Grier, William K.;Mahmassani, Ziad;Boppart, Marni D.;Harley, Brendan A. C.
通讯作者：
Harley, Brendan A. C.
影响因子：
2.4
作者：
Benjamin, M;Toumi, H;Milz, S
通讯作者：
Milz, S
DOI：
10.1002/jbm.820290915
发表时间：
1995-09-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
CHU, CR;COUTTS, RD;AMIEL, D
通讯作者：
AMIEL, D
影响因子：
6.7
作者：
Baldino, Lucia;Cardea, Stefano;Reverchon, Ernesto
通讯作者：
Reverchon, Ernesto
影响因子：
14
作者：
Brown, Bryan N.;Valentin, Jolene E.;Stewart-Akers, Ann M.;McCabe, George P.;Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.