Prenatal phenol and phthalate exposures and birth outcomes.
Prenatal phenol and phthalate exposures and birth outcomes.
复制标题
产前苯酚和邻苯二甲酸盐暴露和出生结果。
DOI：
10.1289/ehp.11007
复制
发表时间：
2008-08
影响因子：
10.4
通讯作者：
Calafat, Antonia M.
中科院分区：
文献类型：
--
作者：
Wolff, Mary S.;Engel, Stephanie M.;Berkowitz, Gertrud S.;Ye, Xiaoyun;Silva, Manori J.;Zhu, Chenbo;Wetmur, James;Calafat, Antonia M.
许多邻苯二甲酸酯和酚类物质具有生殖活性，并被怀疑会改变发育过程。我们调查了产前邻苯二甲酸酯和苯酚代谢物的暴露及其与出生时婴儿体型测量的相关性。我们测量了纽约市404名妇女在妊娠晚期的多种族队列中的5种苯酚和10种邻苯二甲酸酯尿代谢物，并记录了出生时婴儿的大小。5种酚类代谢物中有2种和10种邻苯二甲酸单酯代谢物中有6种的尿中浓度> 10 μg/L。低分子量邻苯二甲酸单酯（低MWP）的浓度约为高分子量代谢物的5倍。低MWP代谢物与胎龄[每种ln生物标志物的胎龄为0.97天; 95%置信区间（CI）为0.07-1.9天，多变量校正]和头围呈正相关。产前接触2，5-二氯苯酚（2，5-DCP）越多，男孩的出生体重越低（2，5-DCP的第三个三分位数和第一个三分位数之间的平均出生体重差为-210 g; 95% CI，71-348 g）。较高的母体二苯甲酮-3（BP 3）浓度与女孩出生体重的类似下降有关，但与男孩出生体重的增加有关。我们观察到一系列邻苯二甲酸酯和苯酚暴露在怀孕期间，在我们的人口，但很少与出生大小。2，5-DCP和BP 3与出生体重减少或增加的关联在非常早期或小尺寸的出生中可能是重要的。此外，尿代谢产物与某些结果的正相关可能部分归因于未解决的母体人体测量因素的混杂。
Many phthalates and phenols are hormonally active and are suspected to alter the course of development. We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth. We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth. Median urinary concentrations were > 10 μg/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07–1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (−210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71–348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys. We observed a range of phthalate and phenol exposures during pregnancy in our population, but few were associated with birth size. The association of 2,5-DCP and BP3 with reduced or increased birth weight could be important in very early or small-size births. In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors.
登录
查看更多内容
影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
2.9
作者：
Ferguson, SA;Flynn, KM;Newbold, RR
通讯作者：
Newbold, RR
DOI：
10.1080/00039896.1995.9935954
发表时间：
1995-07-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
HILL, RH;ASHLEY, DL;PIRKLE, JL
通讯作者：
PIRKLE, JL
影响因子：
6.6
作者：
Hsieh, Michael H.;Grantham, Erin C.;Baskin, Laurence S.
通讯作者：
Baskin, Laurence S.
影响因子：
7.4
作者：
Kuklenyik, Z;Ekong, J;Calafat, AM
通讯作者：
Calafat, AM